LARP4 Inhibitors
Chemical inhibitors of LARP4 function mainly by disrupting various stages of the mRNA translation process, which is integral to the protein's role in mRNA stabilization and poly(A) tail length regulation. Blebbistatin, by inhibiting non-muscle myosin II, affects cytoskeletal rearrangements that are necessary for the proper functioning of LARP4 in translation initiation. Latrunculin A contributes to this disruption by binding to actin monomers, preventing their polymerization and consequently impacting the actin dynamics essential for LARP4-associated mRNA stability. Paclitaxel, on the other hand, hyperstabilizes microtubules, potentially interfering with microtubule-dependent processes that LARP4 might utilize for its role in mRNA translation and stability. Rocaglamide and Silvestrol exert their effects by inhibiting the activity of eukaryotic initiation factor 4A (eIF4A), which is necessary for the mRNA translation process in which LARP4 is involved. This inhibition can impair LARP4's function in the translation machinery.
Furthermore, Homoharringtonine and Harringtonine target the elongation phase of protein synthesis, where Homoharringtonine disrupts the alignment of aminoacyl-tRNAs with the ribosomal A site, and Harringtonine blocks the peptidyl transferase reaction, both leading to an inhibition of the protein synthesis process that involves LARP4. Cycloheximide impedes the translocation step in protein synthesis on eukaryotic ribosomes, thereby potentially inhibiting the elongation process crucial for LARP4's function. Emetine brings about its inhibitory action by blocking ribosomal movement along mRNA, which is a fundamental step in the translation process where LARP4 is implicated. Puromycin causes premature termination of the growing polypeptide chain, which can disrupt mRNA translation and consequently LARP4's function in mRNA stabilization. Anisomycin inhibits peptidyl transferase on the 60S ribosomal subunit, which is essential for LARP4's function in translation. Lastly, Sordarin impedes the function of eukaryotic elongation factor 2 (eEF2), essential for the translocation of ribosomes along mRNA, thereby affecting the translation process in which LARP4 is involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin inhibits non-muscle myosin II, which is crucial for cytoskeletal rearrangements. By inhibiting this myosin, Blebbistatin can impede the translation initiation processes where LARP4 is involved, leading to the functional inhibition of LARP4's role in mRNA stabilization and poly(A) tail length regulation. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization, disrupting actin dynamics. Since LARP4 has been implicated in mRNA stabilization associated with cytoskeletal elements, the disruption of actin filaments can inhibit the function of LARP4 in maintaining mRNA stability. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and inhibits their disassembly. By hyperstabilizing microtubules, it can interfere with microtubule-dependent processes, which may be essential for LARP4-mediated mRNA translation and stability, thus functionally inhibiting LARP4. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $270.00 $465.00 $1607.00 $2448.00 $5239.00 | 4 | |
Rocaglamide inhibits eukaryotic initiation factor 4A (eIF4A), which is necessary for mRNA translation. By inhibiting eIF4A, Rocaglamide can suppress the translation machinery that LARP4 is a part of, thereby inhibiting LARP4's function in mRNA translation and stabilization. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $51.00 $123.00 $178.00 | 11 | |
Homoharringtonine inhibits the initial elongation step of protein synthesis by preventing the proper alignment of aminoacyl-tRNAs with the A site of the ribosome. This action can inhibit the protein synthesis process involving LARP4, thereby functionally inhibiting its role in translation and mRNA stabilization. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits the translocation step in protein synthesis on eukaryotic ribosomes. By preventing elongation, Cycloheximide can inhibit the translation process that involves LARP4, leading to functional inhibition of LARP4's activity in mRNA stabilization. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $352.00 $566.00 $1331.00 $2453.00 | ||
Emetine irreversibly inhibits eukaryotic ribosomal movement along mRNA. This inhibition can disrupt the translation process in which LARP4 is involved, leading to its functional inhibition in terms of mRNA translation and stabilization. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Puromycin causes premature chain termination during translation by acting as an analog of aminoacyl-tRNA. This action can inhibit the translation process in which LARP4 functions, thereby functionally inhibiting LARP4's activity in mRNA stabilization. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin inhibits peptidyl transferase activity on the 60S ribosomal subunit. By inhibiting this enzyme, Anisomycin can disrupt the translation process, which is crucial for LARP4 function, leading to its functional inhibition in mRNA stabilization. | ||||||
Sordarin sodium salt | 463356-00-5 | sc-253601 | 5 mg | $546.00 | 2 | |
Sordarin inhibits eukaryotic elongation factor 2 (eEF2), which is involved in the translocation of the ribosome along mRNA. By inhibiting eEF2, Sordarin can disrupt the translation process and functionally inhibit LARP4's involvement in mRNA translation and stability. | ||||||