LALP1 Activators
LALP1 Activators are a class of compounds that indirectly enhance the functional activity of the protein LALP1 through various signaling pathways. Forskolin, by increasing intracellular cAMP levels, can activate PKA - a kinase that may phosphorylate LALP1, leading to its enhanced activity. Similarly, rolipram and IBMX raise cAMP levels, possibly augmenting LALP1 activity if LALP1 is part of the cAMP/PKA signaling axis. PMA, through the activation of PKC, and ionomycin, by raising intracellular calcium, can activate kinases that may target LALP1 for phosphorylation. EGF and insulin represent growth factors that, through their respective receptor signaling pathways, could activate PI3K/Akt or other kinases that phosphorylate and activate LALP1.
On the other hand, sodium fluoride and anisomycin act through the activation of different kinases, such as PKA and JNK respectively, which could phosphorylate LALP1, assuming it is a substrate for these kinases. Calyculin A and okadaic acid inhibit protein phosphatases, leading to a net increase in phosphorylated proteins - this could result in the sustained activity of LALP1 if it is regulated by phosphorylation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP can enhance LALP1 activity if LALP1 is a cAMP-dependent protein kinase A (PKA) substrate. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, leading to an accumulation of cAMP. This could enhance the activity of LALP1 if LALP1 is regulated by the cAMP/PKA signaling pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which increases intracellular cAMP and cGMP levels, potentially enhancing LALP1 activity through these signaling molecules. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which could lead to the phosphorylation and activation of LALP1 if it is a substrate of PKC. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent kinases that may phosphorylate and activate LALP1. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, potentially enhancing LALP1 activity if LALP1 is a downstream effector in this pathway. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium fluoride activates various kinases, including PKA, which could lead to the activation of LALP1 if it is a PKA substrate. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator. If LALP1 is regulated by the JNK pathway, anisomycin could enhance its activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A, which could lead to an increase in the phosphorylated (and active) state of LALP1 if it is normally regulated by dephosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases, which could result in enhanced activity of LALP1 through increased phosphorylation. | ||||||