LACTB Activators
LACTB Activators encompass a variety of chemical compounds that indirectly enhance the functional activity of LACTB through distinct signaling pathways and cellular processes, predominantly in mitochondrial lipid metabolism. Forskolin, by raising cAMP levels, activates PKA, which may phosphorylate proteins that interact with LACTB, thereby augmenting its enzymatic function. Similarly, sphingosine-1-phosphate signals via its receptors to adjust mitochondrial dynamics, consequently promoting LACTB's role in lipid processing. Retinoic acid and PPAR agonists like Pioglitazone activate transcriptional programs and lipid metabolism pathways that can bolster LACTB's activity. The integrity of mitochondrial membranes, supported by cardiolipin, is essential for LACTB's functionality, while NADH indicates heightened metabolic activity, potentially necessitating increased LACTB action. Oligomycin's inhibition of ATP synthase alters mitochondrial function, which may indirectly lead to an enhanced need for LACTB's role in energy balance.
Furthermore, the calcium ionophore A23187 elevates intracellular calcium levels, stimulating calcium-dependent pathways that may affect LACTB activity. Antioxidants such as Alpha-lipoic acid and compounds like NMN that increase NAD+ levels both support mitochondrial bioenergetics, potentially amplifying LACTB's functional capacity. Leptin, by modulating energy homeostasis, can create a demand for LACTB-mediated lipid processing in mitochondria. Lastly, Resveratrol, through its influence on sirtuin pathways, contributes to the regulation of mitochondrial function, which may indirectly elevate LACTB activity. Collectively, these compounds, through their targeted effects on various biochemical and cellular pathways, facilitate the enhancement of LACTB-mediated processes crucial for maintaining mitochondrial integrity and lipid metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate substrates that may include those interacting with LACTB, thereby enhancing LACTB's enzymatic activity involved in mitochondrial lipid metabolism. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate acts through its receptors to activate signaling pathways involved in mitochondrial dynamics. This activation can lead to changes in mitochondrial morphology and function, potentially enhancing the role of LACTB in mitochondrial lipid processing. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences gene expression through retinoic acid receptors and can lead to the upregulation of proteins involved in mitochondrial function, which could include an indirect enhancement of LACTB activity within the mitochondria. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone is a PPARγ agonist that modulates lipid metabolism. Activation of PPARγ may lead to a metabolic shift that requires enhanced mitochondrial lipid processing, thereby potentially increasing the activity of LACTB. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NADH is a central cofactor in mitochondrial energy metabolism. Elevated levels of NADH in the mitochondria can indicate increased metabolic activity, possibly necessitating enhanced LACTB activity for efficient lipid processing. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin inhibits ATP synthase, leading to an increase in mitochondrial membrane potential. This alteration in mitochondrial function can indirectly necessitate an increase in LACTB activity as the cell attempts to maintain energy balance. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore A23187 increases intracellular calcium, which can activate calcium-dependent signaling pathways. These pathways may intersect with those regulating mitochondrial function and LACTB activity. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-lipoic acid is an antioxidant that is also involved in mitochondrial bioenergetics. It can enhance mitochondrial function and thus may indirectly boost LACTB's activity in lipid metabolism within the organelle. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN is a precursor to NAD+, which is involved in mitochondrial energy metabolism. Supplementing with NMN can increase NAD+ levels, potentially enhancing mitochondrial function and LACTB activity. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $253.00 | 1 | ||
Leptin is involved in energy homeostasis and can influence mitochondrial function. Its signaling may lead to a metabolic state that requires increased LACTB activity for lipid processing within mitochondria. | ||||||