L3MBTL Activators
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1), is a protein that is encoded by the L3MBTL1 gene in humans. This protein is part of the MBT family, which is characterized by a specific protein domain known as the malignant brain tumor (MBT) repeat. The MBT repeat is known to bind to methylated lysine residues on histone proteins, suggesting a role for these proteins in reading the histone code and thereby influencing chromatin structure and gene expression.L3MBTL1 is known to play a role in transcriptional repression, meaning it can inhibit the transcription of certain genes. This is often associated with the compacting of chromatin structure, making it less accessible to the transcription machinery.
In addition, L3MBTL1 has been implicated in cell cycle regulation. It is known to interact with the retinoblastoma protein (RB), a key regulator of the cell cycle, and this interaction may contribute to its role in cell cycle control.Alterations in L3MBTL1 have been associated with certain diseases. For example, deletions involving the L3MBTL1 gene have been identified with myeloid malignancies. Moreover, L3MBTL1 is located in a region of chromosome 20 that is often deleted in myeloid malignancies, suggesting a potential role in the development of these cancers.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a DNA methyltransferase inhibitor, potentially affecting epigenetic regulation and indirectly influencing L3MBTL activity. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAMe serves as a methyl donor in various biological processes, potentially influencing methylation patterns relevant to L3MBTL function. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is another HDAC inhibitor, which could affect chromatin remodeling and indirectly modulate L3MBTL activity. | ||||||
Methylstat | 1310877-95-2 | sc-507374 | 10 mg | $480.00 | ||
Methylstat is an inhibitor of Jumonji C domain-containing histone demethylases, potentially affecting histone methylation status and L3MBTL activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor, which might indirectly influence the epigenetic regulation processes involving L3MBTL. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294 is a G9a histone methyltransferase inhibitor, potentially affecting histone methylation and L3MBTL-related pathways. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 inhibits the BET family of bromodomain proteins, potentially influencing transcription and chromatin states relevant to L3MBTL. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a potent HDAC inhibitor, which could impact chromatin dynamics and indirectly affect L3MBTL. | ||||||