L-type Calcium Channel γ Inhibitors
Chemical inhibitors of the L-type Calcium Channel γ subunit include a range of calcium channel blockers that are structurally diverse yet share a common mechanism of action. Nifedipine, Verapamil, Amlodipine, Isradipine, Diltiazem, Nicardipine, Felodipine, Nimodipine, Lacidipine, Azelnidipine, and Lercanidipine all bind to the L-type calcium channels and inhibit the passage of calcium ions through these channels. By obstructing these ion channels, these compounds decrease the flow of calcium ions into cells, which is critical for the initiation and maintenance of muscle contraction. The action of inhibiting the main channel complex naturally extends to the inhibition of the L-type Calcium Channel γ subunit, given its integral role in the channel complex's structure and function.
The binding of these inhibitors to the L-type calcium channels alters the conformation of the channel in such a way that it impedes the opening of the channel, thereby reducing calcium ion conductance. As the L-type Calcium Channel γ subunit is a part of this complex, its function is consequently inhibited when the calcium channel blockers exert their effects on the channel. Inhibiting the L-type Calcium Channel γ subunit affects its contribution to the overall operation of the channel complex. The precise interactions and binding affinities vary among the different inhibitors, although the end result is a consistent decrease in the activity of the L-type Calcium Channel γ subunit. Each of these inhibitors contributes to the modulation of the channel's activity through direct interaction with the L-type calcium channels, and by extension, the L-type Calcium Channel γ subunit within the complex.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine inhibits L-type calcium channels, which are present in various tissues including cardiac and smooth muscle. By inhibiting these channels, nifedipine reduces the influx of calcium ions which are necessary for muscle contraction. Since the L-type Calcium Channel γ is a subunit of the L-type calcium channel complex, inhibiting the main channel's function also inhibits the function of the γ subunit. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil binds to and blocks L-type calcium channels, which impairs the channel's ability to permit calcium ion passage into the cell. This blockade of calcium influx results in a decrease in intracellular calcium levels, which is crucial for various cellular processes including muscle contraction. Since the L-type Calcium Channel γ is part of the L-type calcium channel complex, the inhibition of the channel by verapamil consequently inhibits the γ subunit's associated functions. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $73.00 $163.00 | 2 | |
Amlodipine selectively inhibits the calcium ion influx through L-type calcium channels. By doing so, it decreases the contractile function of cardiac and smooth muscle that depends on calcium ions. Inhibition of the main channel complex by amlodipine means that the activity of the L-type Calcium Channel γ, which is a component of the complex, is also inhibited. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $86.00 $318.00 | 1 | |
Isradipine exhibits high affinity for L-type calcium channels and inhibits their activity by blocking the entry of calcium ions. The L-type Calcium Channel γ, as a part of the overall channel complex, is also inhibited when isradipine blocks the calcium ion flow through the channel, thereby affecting muscle contractility and other calcium-dependent processes. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem inhibits the flow of calcium ions through L-type calcium channels by binding to these channels and impeding their opening. This inhibition lowers intracellular calcium levels and therefore muscle contraction. As L-type Calcium Channel γ is part of this channel complex, the inhibition of calcium ion flow by diltiazem inevitably leads to the inhibition of the γ subunit's function. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $32.00 $81.00 | 5 | |
Nicardipine is an L-type calcium channel blocker that inhibits the influx of calcium ions through these channels. In doing so, it prevents muscular contraction which is dependent on calcium ions. This inhibition of the L-type calcium channels indirectly leads to the inhibition of the L-type Calcium Channel γ subunit, as it is an integral component of the L-type calcium channel complex. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $89.00 $218.00 | 1 | |
Felodipine binds to L-type calcium channels, inhibiting calcium ion entry and thereby reducing vascular smooth muscle contractility. The L-type Calcium Channel γ is part of the overall channel complex, and its function is inhibited when felodipine prevents calcium entry through the main channel. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $60.00 $301.00 | 2 | |
Nimodipine selectively inhibits L-type calcium channels, and this inhibition reduces the intracellular calcium ion concentration which is essential for muscle contraction and other cellular functions. By inhibiting the main L-type calcium channel, nimodipine also inhibits the L-type Calcium Channel γ subunit within the complex. | ||||||
trans Lacidipine | 103890-78-4 | sc-213066 | 10 mg | $153.00 | ||
Lacidipine is an L-type calcium channel blocker that impedes calcium ion influx, directly inhibiting the channel's ability to facilitate calcium ion entry into cells. This inhibition of the L-type channels indirectly inhibits the function of the L-type Calcium Channel γ subunit by preventing its normal operation within the channel complex. | ||||||
Azelnidipine | 123524-52-7 | sc-252395 | 10 mg | $86.00 | ||
Azelnidipine inhibits L-type calcium channels, reducing the influx of calcium ions and the subsequent muscular contraction that relies on calcium. As the L-type Calcium Channel γ is part of the L-type calcium channel complex, the inhibition of the main channel by azelnidipine also inhibits the γ subunit. | ||||||