KRTAP5-6 Inhibitors
KRTAP5-6 inhibitors encompass a variety of compounds that influence cellular signaling pathways and processes indirectly related to the function of KRTAP5-6. Protein kinase inhibitors like staurosporine can disrupt the phosphorylation status of proteins within hair follicle cells, potentially impacting the structural integrity where KRTAP5-6 is involved. PI3K inhibitors such asLY294002 and wortmannin suppress the AKT pathway, which is integral to protein synthesis and turnover, thereby possibly reducing the functional activity of KRTAP5-6 by impairing hair follicle protein maintenance. mTOR inhibitors like rapamycin disrupt protein synthesis directly, which could limit the production and repair of structural proteins including KRTAP5-6, essential for hair structure. JNK and p38 MAPK inhibitors (Sp600125 and SB203580, respectively) could alter the cell's stress response with potential repercussions on the structural maintenance of hair follicles, thereby affecting KRTAP5-6's role. MEK inhibitors such as PD98059 and U0126, by inhibiting ERK activation, may impede the signaling required for maintaining hair structure integrity, which is essential for proper function of KRTAP5-6.
Further, compounds like cyclosporin A modulate the immune function, which can indirectly influence hair follicle health and, consequently, KRTAP5-6 activity. Histone deacetylase inhibitors, exemplified by trichostatin A, can alter gene expression profiles, potentially leading to changes in KRTAP5-6 expression and function in hair follicles. Proteasome inhibitors like MG132 and bortezomib result in the accumulation of damaged proteins, leading to cellular stress which could affect hair follicle health and KRTAP5-6 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases. KRTAP5-6, being a hair keratin associated protein, would have its function influenced by the phosphorylation state of various proteins in hair follicle cells. Staurosporine inhibits these protein kinases, thereby potentially altering the phosphorylation patterns that could inhibit proper functioning of KRTAP5-6 in the structural integrity of hair. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, a key component in the AKT signaling pathway. By inhibiting PI3K, this compound suppresses AKT activation. Since AKT can influence cellular processes including protein synthesis and turnover, the inhibition by LY294002 could lead to a reduced function of KRTAP5-6 as the hair follicle cells may not maintain structural proteins efficiently. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, which acts similarly to LY294002 but is structurally different and more potent. Its inhibitory action on PI3K can lead to a decrease in the activities within the AKT pathway, potentially resulting in decreased functional capacity of KRTAP5-6 due to impaired protein maintenance in hair follicles. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. mTOR is a central protein for cell growth and protein synthesis. Inhibition by rapamycin could diminish the synthesis and repair of keratin proteins including KRTAP5-6, thus impairing its function in hair structure. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Sp600125 is an inhibitor of JNK, part of the MAPK signaling pathway. By inhibiting JNK, this compound can affect the cell stress response, which could potentially impact the integrity of structural proteins like KRTAP5-6 in hair follicles. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Its inhibition of p38 MAPK can influence inflammatory responses and could indirectly affect the structural maintenance of hair follicles, thereby potentially inhibiting the functional activity of KRTAP5-6. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, which indirectly inhibits ERK, another kinase within the MAPK pathway. Through the inhibition of ERK, PD98059 could impair cellular responses to stress and thus could lead to inhibition of KRTAP5-6 function in hair follicle integrity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that prevents the activation of ERK. By doing so, it could hinder protein signaling necessary for the maintenance of hair structure, which could result in the inhibition of KRTAP5-6 activity. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an immunosuppressant that binds to the cyclophilins and inhibits calcineurin. By doing so, it can interfere with T-cell activation pathways. As hair growth can be influenced by immune signaling, the use of cyclosporin A might indirectly inhibit KRTAP5-6 function in hair follicles by altering the immune environment. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which can change the expression of various genes. By altering gene expression profiles, it could indirectly affect the expression and function of structural proteins such as KRTAP5-6 in hair follicles. | ||||||