KRTAP5-3 Inhibitors
KRTAP5-3 inhibitors encompass a variety of chemical compounds that impinge upon the function of the hair-specific keratin-associated protein KRTAP5-3 by modulating different signaling pathways and cellular processes. These inhibitors do not directly target KRTAP5-3, but rather affect its activity by altering the cellular context in which KRTAP5-3 operates or by influencing the expression and stability of the protein. For instance, Staurosporine, although a broad-spectrum kinase inhibitor, can affect the phosphorylation status of proteins that interact with keratins, potentially destabilizing the complex network necessary for KRTAP5-3 function. Similarly, LY294002's inhibition of PI3K could result in diminished Akt signaling, creating an environment less conducive to the stability and function of keratin-associated proteins like KRTAP5-3.
The impact of these inhibitors is also reflected in the control of gene expression and protein synthesis. Trichostatin A, through histone deacetylase inhibition, can alter gene expression patterns, potentially decreasing the transcription of genes encoding KRTAP5-3. Furthermore, compounds like Cycloheximide and Rapamycin directly inhibit protein synthesis pathways, which could lead to a general reduction in the expression of KRTAP5-3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an EGFR inhibitor that may indirectly inhibit KRTAP5-3 by reducing the EGFR signaling pathway, which is crucial for keratinocyte proliferation and differentiation. Reduced signaling could lead to decreased expression of keratin-associated proteins like KRTAP5-3. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib is a tyrosine kinase inhibitor known to target c-Abl and PDGFR. By inhibiting these kinases, it could adversely affect the cellular architecture that supports the structural integrity of keratin, which may result in diminished stability and function of KRTAP5-3. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is part of the pathway that regulates protein synthesis and cell growth. Inhibition of mTOR can decrease the synthesis of proteins, potentially leading to lower levels of KRTAP5-3. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2 which disrupts the MAPK/ERK pathway. This pathway is involved in cell growth and differentiation, and its inhibition can result in decreased cellular processes that involve KRTAP5-3. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an HDAC inhibitor that can alter chromatin structure and affect gene expression. Its effect on chromatin can lead to decreased expression of proteins like KRTAP5-3 by changing the accessibility of transcriptional machinery. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can lead to the accumulation of misfolded proteins, triggering cellular stress responses. This can adversely affect the cellular environment of KRTAP5-3, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that may diminish Akt pathway signaling, which is involved in cell survival and protein synthesis. By inhibiting PI3K, LY294002 may reduce the stability and function of KRTAP5-3. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, which could lead to decreased levels of KRTAP5-3. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a protein kinase C inhibitor. Since PKC is involved in multiple signaling pathways that regulate cellular processes, including keratinization, its inhibition can lead to decreased expression and function of KRTAP5-3. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a RAF kinase inhibitor that indirectly affects the ERK/MAPK pathway. By inhibiting RAF, Sorafenib can disrupt downstream signaling that regulates cell differentiation, potentially reducing the functional activity of KRTAP5-3. | ||||||