KRTAP5-11 Activators
KRTAP5-11 engage with various molecular mechanisms to influence its activity within the hair follicle. Benzalkonium chloride interacts directly with cell membranes, increasing their permeability, which in turn facilitates the activation of KRTAP5-11 by enhancing the accessibility of the protein to its substrates within the hair structure. Concurrently, retinoic acid, known for regulating keratin gene expression, promotes the structural integrity and function of keratin-based structures, leading to the activation of keratin-associated proteins such as KRTAP5-11, which plays a pivotal role in hair fiber formation. Zinc pyrithione interacts with keratin to stabilize its structure, further supporting the activation of KRTAP5-11 as it contributes to the hair's structural composition.
Minoxidil, known for its ability to open potassium channels, influences hair follicle cells, which can lead to the activation of proteins like KRTAP5-11 that are integral to hair growth and maintenance. Similarly, the copper peptide (GHK-Cu) stimulates hair growth, potentially enhancing the activation of KRTAP5-11 by promoting hair follicle cell proliferation and protein stabilization. Meanwhile, caffeine stimulates hair follicle growth by targeting pathways that affect hair loss and enhancing energy metabolism, which can promote the activation of KRTAP5-11 due to its involvement in hair structural protein composition. Niacinamide and panthenol both have supportive roles in improving hair structure, with niacinamide improving skin barrier function and panthenol strengthening hair and improving elasticity, both leading to the activation of KRTAP5-11. Furthermore, taurine, biotin, and L-Cysteine contribute to the development, structure, and stability of hair follicles, thereby supporting the activation of KRTAP5-11. Biotin does so by enhancing keratin infrastructure, L-Cysteine by contributing to disulfide bond formation in keratin, and taurine by contributing to the structural stability of keratin-associated proteins in the hair shaft. Lastly, pantothenic acid is involved in the metabolic processes that provide energy and facilitate the turnover of structural proteins, which, in tandem, can activate KRTAP5-11 within hair follicles.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzalkonium chloride | 63449-41-2 | sc-257126 | 100 g | $79.00 | ||
Benzalkonium chloride interacts with the cell membrane, potentially leading to increased cellular permeability and facilitating the activation of KRTAP5-11 as it may enhance the accessibility of the protein to its substrates or interaction partners within the hair follicle structure. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, being a known regulator of keratin gene expression, may enhance the structural integrity and function of keratin-based structures, which could result in the activation of keratin-associated proteins like KRTAP5-11 involved in hair fiber formation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc pyrithione can bind to keratin and may thereby stabilize the keratin structure, which could lead to the activation of KRTAP5-11, as it is involved in the structural composition of hair. | ||||||
Minoxidil (U-10858) | 38304-91-5 | sc-200984 sc-200984A | 100 mg 1 g | $68.00 $344.00 | ||
Minoxidil has been shown to open potassium channels, which may influence hair follicle cells and potentially lead to the activation of keratin-associated proteins like KRTAP5-11 in the process of hair growth and maintenance. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine can stimulate hair follicle growth by targeting DHT pathways and enhancing energy metabolism, which may promote the activation of KRTAP5-11 due to its role in hair structural protein composition. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Niacinamide improves skin barrier function and could activate KRTAP5-11 by increasing the resilience and structure of hair follicles, where KRTAP5-11 is a constitutive protein. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $47.00 $100.00 | 1 | |
Taurine has been implicated in hair follicle development and may activate KRTAP5-11 by contributing to the structural stability and function of keratin-associated proteins in the hair shaft. | ||||||
D-(+)-Biotin | 58-85-5 | sc-204706 sc-204706A sc-204706B | 1 g 5 g 25 g | $40.00 $105.00 $326.00 | 1 | |
Biotin enhances keratin infrastructure, which could lead to the activation of KRTAP5-11, reflecting its supportive role in the structural matrix of hair. | ||||||
L-Cysteine | 52-90-4 | sc-286072 sc-286072A sc-286072B sc-286072C sc-286072D | 25 g 100 g 500 g 5 kg 10 kg | $50.00 $110.00 $440.00 $1128.00 $2135.00 | 1 | |
L-Cysteine is a sulfur-containing amino acid that contributes to the disulfide bonds in keratin structure, possibly resulting in the activation of KRTAP5-11 by promoting the stability and function of hair keratins. | ||||||