KRTAP4-8 Inhibitors
KRTAP4-8 inhibitors, Disulfiram and Iodoacetamide, target aldehyde groups and cysteine residues, respectively, which can modify the structural integrity essential for KRTAP4-8's role in hair fiber formation. Dithiothreitol (DTT) and Phenylarsine oxide, through their actions on disulfide bonds and vicinal thiol proteins, can disrupt the tertiary structure and function of KRTAP4-8.
Genistein and Staurosporine, as kinase inhibitors, can affect the phosphorylation state of KRTAP4-8, a post-translational modification that could influence protein interactions and function. Retinoic acid, by modulating gene expression, can affect the hair follicle cycle, potentially impacting the expression levels of KRTAP4-8. Mimosine and MG-132, by inhibiting cell proliferation and proteasomal degradation, respectively, may affect the availability and stability of KRTAP4-8 within the cell. Furthermore, Dimethyl sulfoxide (DMSO)'s ability to disrupt protein-protein interactions and Cadmium chloride's induction of oxidative stress can lead to changes in the structural conformation and function of KRTAP4-8. Tunicamycin's role in inhibiting glycosylation can affect the post-translational modification of KRTAP4-8, potentially altering its stability and function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Inhibits aldehyde dehydrogenase; can affect protein cross-linking by modifying aldehyde groups, potentially altering KRTAP4-8 structure. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Tyrosine kinase inhibitor; can affect phosphorylation processes, possibly influencing KRTAP4-8 interactions. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $250.00 | 1 | |
Alkylates cysteine residues; can affect protein structure by preventing disulfide bond formation, potentially altering KRTAP4-8. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $35.00 $86.00 $216.00 $427.00 | 8 | |
Iron chelator and amino acid analog; can inhibit cell proliferation, potentially affecting KRTAP4-8 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Modulates gene expression; can influence hair follicle cycling and protein expression, including KRTAP4-8. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Protein kinase inhibitor; can inhibit a wide range of kinases, potentially affecting the phosphorylation state of KRTAP4-8. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $40.00 | 4 | |
Inhibitor of vicinal thiol proteins; can affect protein function by binding to cysteine residues, potentially influencing KRTAP4-8. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor; can affect protein degradation pathways, potentially increasing the stability of KRTAP4-8. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
Solvent that can penetrate biological membranes; can disrupt protein-protein interactions, potentially influencing KRTAP4-8. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Metal ion that can induce oxidative stress; can affect protein structure and function, potentially altering KRTAP4-8. | ||||||