KRTAP24-1 Inhibitors
KRTAP24-1 inhibitors represent a class of chemical compounds designed to target and inhibit the activity of the keratin-associated protein 24-1 (KRTAP24-1). KRTAPs are a family of proteins involved in the structure and formation of keratin filaments, which play a critical role in the rigidity and resilience of hair and other keratinized tissues. Specifically, KRTAP24-1 is one of the many members of this protein family, characterized by its high cysteine content, contributing to disulfide bond formation, which in turn stabilizes the keratin network. Inhibitors targeting KRTAP24-1 likely function by interfering with its ability to bind or interact with keratin filaments, thereby modulating the overall structure and mechanical properties of keratinized tissues. These inhibitors may have the capacity to alter the structural configuration of keratin by preventing the proper integration of KRTAP24-1 within the keratin matrix.
In terms of chemical design, KRTAP24-1 inhibitors can encompass a range of small molecules, peptides, or other macromolecular structures capable of specifically binding to the active or binding sites of KRTAP24-1. The inhibition mechanism might involve competitive binding at cysteine-rich regions or blocking protein-protein interactions essential for KRTAP24-1 function. Understanding the chemical structure of these inhibitors is important for elucidating how they disrupt the structural role of KRTAP24-1, which may depend on their ability to interact with key residues or alter the conformational dynamics of the protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor could downregulate KRTAP24-1 by promoting a more closed chromatin state, hindering the access of transcription machinery to the KRTAP24-1 gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, this chemical could decrease DNA methylation levels at the KRTAP24-1 gene locus, potentially leading to transcriptional silencing. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A could decrease KRTAP24-1 expression by binding to GC-rich DNA sequences in the gene's promoter, obstructing the initiation of transcription. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting the mTOR pathway, rapamycin could indirectly decrease the translation rate of many proteins, including KRTAP24-1, by reducing the overall protein synthesis capacity of the cell. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could downregulate KRTAP24-1 by binding to retinoic acid receptors that alter the transcription of genes involved in hair follicle development. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
This aldosterone antagonist may reduce the expression of KRTAP24-1 by altering hormonal signaling pathways that govern the structural protein expression in tissues like hair. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole, by inhibiting cytochrome P450 enzymes involved in steroid synthesis, could decrease the expression of KRTAP24-1 by altering the local hormone milieu that controls hair follicle gene expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
This ribonucleotide reductase inhibitor could decrease KRTAP24-1 expression by disrupting the DNA synthesis phase of the cell cycle, leading to broader downregulation of DNA replication-dependent gene expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid could downregulate the expression of KRTAP24-1 through its action as an HDAC inhibitor, thereby changing the epigenetic state of the gene and reducing transcriptional activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
This chemical could decrease KRTAP24-1 expression by inhibiting GSK-3β, which might subsequently alter signaling pathways and transcription factor activities linked to hair follicle gene expression. | ||||||