KRTAP21-3 Inhibitors
KRTAP21-3 inhibitors are a class of chemical compounds that specifically target and modulate the activity of the KRTAP21-3 protein, which belongs to the keratin-associated protein (KRTAP) family. The KRTAP family plays a key role in the structural integrity of hair and nails by interacting with keratin fibers. KRTAP21-3, in particular, is part of a group that binds to type I and type II keratins, influencing the rigidity and resilience of the hair fiber matrix. Inhibitors of KRTAP21-3 act by disrupting its interaction with keratin filaments, thereby altering the overall architecture and mechanical properties of keratinized structures. These inhibitors can vary in their mechanisms, ranging from small molecules that bind directly to the protein's active sites to allosteric modulators that affect the conformational dynamics of the protein without directly occupying its binding sites.
The chemical structure of KRTAP21-3 inhibitors typically includes motifs that facilitate high-affinity binding to the KRTAP proteins, ensuring specificity for this particular member of the keratin-associated protein family. Their design may incorporate elements that allow selective interaction with KRTAP21-3 over other KRTAP members or keratin types, minimizing off-target effects. Molecular interactions often involve hydrophobic contacts and hydrogen bonding within the protein's binding domains, stabilizing the inhibitor-protein complex. These inhibitors are valuable tools in research applications for investigating the specific biological pathways that KRTAP21-3 is involved in, providing insight into the structural and functional relationships between KRTAP proteins and keratin fibers in various physiological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alizarin | 72-48-0 | sc-214519 sc-214519A | 1.5 g 100 g | $21.00 $51.00 | ||
Alizarin interacts with calcium ions, potentially inhibiting the mineralization process in which Keratin-associated protein 21-3 is involved, thereby leading to the functional inhibition of this protein's ability to associate with hair shaft keratinization. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $161.00 $312.00 $1210.00 | 9 | |
Cerulenin inhibits fatty acid synthase, an enzyme necessary for lipid biosynthesis. Since Keratin-associated protein 21-3 is involved in the structural integrity of hair that requires lipid interactions, inhibition of lipid biosynthesis can disrupt the function of Keratin-associated protein 21-3 in maintaining hair structure. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $36.00 $88.00 $220.00 $436.00 | 8 | |
Mimosine inhibits the synthesis of polyamines, which are essential for hair follicle growth and keratinization. By this action, it can inhibit the proper assembly and function of Keratin-associated protein 21-3, which is crucial for the structural framework of hair. | ||||||
N-Phenylthiourea | 103-85-5 | sc-236086 | 100 g | $319.00 | ||
Phenylthiourea interferes with the formation of melanin. Given that Keratin-associated protein 21-3 is involved in hair structure and pigmentation, the inhibition of melanin synthesis can affect the proper function of Keratin-associated protein 21-3 in hair pigmentation. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Selenium sulfide is known to disrupt selenoproteins involved in hair follicle function. Given that Keratin-associated protein 21-3 plays a role in hair formation, the disruption of related selenoprotein activity could inhibit the function of Keratin-associated protein 21-3. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation. Even though Keratin-associated protein 21-3 is not glycosylated, the inhibition of glycosylation can disrupt cellular homeostasis and thus indirectly inhibit the proper integration of Keratin-associated protein 21-3 into hair keratin structure. | ||||||
Acitretin | 55079-83-9 | sc-210754 | 25 mg | $151.00 | 1 | |
Acitretin alters keratinocyte differentiation and keratin expression. As Keratin-associated protein 21-3 is a part of the keratin complex in hair fibers, changes in keratin expression and hair follicle dynamics could inhibit the incorporation of this protein into the hair structure. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences keratin gene expression and hair follicle cycle regulation. By altering keratin expression, it could inhibit the proper function and assembly of Keratin-associated protein 21-3 within the hair shaft matrix. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A affects hair growth by targeting immunosuppressive pathways and altering keratinocyte proliferation. As Keratin-associated protein 21-3 is integral to hair shaft formation, changes in keratinocyte dynamics, and proliferation may inhibit the normal function and integration of Keratin-associated protein 21-3 in the hair follicle structure. | ||||||