KRTAP14 Inhibitors
KRTAP14 inhibitors constitute a class of chemical compounds designed to selectively target and interfere with the activity of KRTAP14, a protein belonging to the Keratin-Associated Protein (KRTAP) family. KRTAPs are a diverse group of proteins that associate with keratins and are predominantly expressed in hair and hair follicles.
The primary mechanism of action for KRTAP14 inhibitors typically involves their interaction with the KRTAP14 protein or its associated molecules, leading to the modulation of its normal function. By inhibiting KRTAP14, these compounds have the ability to affect processes related to hair biology or other cellular functions in which this protein is involved. However, the specific roles and molecular pathways associated with KRTAP14 are still areas of active investigation. Scientists studying KRTAP14 inhibitors aim to elucidate the precise functions and significance of KRTAP14 within the context of hair development and other cellular processes. These inhibitors serve as valuable tools for advancing our knowledge of KRTAP14 and its roles in cellular functions. In this context, they contribute to expanding our understanding of the complex interactions and functions of keratin-associated proteins in the biology of hair and other relevant tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to G-C rich regions of DNA, preventing transcription factor binding and RNA polymerase progression, hence could reduce KRTAP14 expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin binds strongly to RNA polymerase II, effectively blocking mRNA synthesis which may reduce expression of genes like KRTAP14. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits the DNA enzyme topoisomerase I, resulting in DNA damage and potential suppression of gene transcription. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB inhibits RNA Polymerase II transcription elongation which could downregulate expression of genes like KRTAP14. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits DNA topoisomerase II, leading to DNA strand breaks and potentially affecting transcription of genes. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone intercalates into DNA and inhibits topoisomerase II, which could suppress gene expression including that of KRTAP14. | ||||||
Aclacinomycin A | 57576-44-0 | sc-200160 | 5 mg | $129.00 | 10 | |
Aclarubicin intercalates into DNA and inhibits RNA polymerase, which could lead to decreased expression of various genes. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a tetracyclic diterpene that specifically inhibits DNA polymerase α and δ, leading to a reduction in DNA synthesis and gene expression. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin binds to the beta subunit of RNA polymerase, inhibiting transcription initiation which may impact the expression of genes like KRTAP14. | ||||||