KRTAP13-2 Activators
KRTAP13-2 activators are compounds that, through various biochemical mechanisms and cellular pathways, can potentially upregulate or enhance the activity of Keratin-associated protein 13-2 (KRTAP13-2). These activators are not unified by a common chemical structure or origin, but rather by their functional impact on the cellular processes governing the expression of KRTAP13-2. They include molecules that influence gene expression by modulating transcription factors or chromatin structure, those that alter signaling pathways impacting keratinocyte differentiation where KRTAP13-2 is involved, and agents that affect epigenetic modifications leading to changes in gene expression patterns. For instance, retinoic acid and isotretinoin, both related to vitamin A metabolism, can bind to nuclear receptors and modify the transcription of genes associated with cell differentiation. Similarly, compounds like dibutyryl cyclic AMP or forskolin can increase intracellular cAMP, thus activating PKA and potentially leading to changes in the expression of KRTAP13-2.
Furthermore, the spectrum of KRTAP13-2 activators includes epigenetic modulators such as 5-Azacytidine and sodium butyrate, which can respectively inhibit DNA methylation and prevent histone deacetylation, thereby promoting a more transcriptionally active chromatin state that could facilitate the expression of KRTAP13-2. Other members of this class include agents like PMA and TPA, known to activate PKC, which plays a significant role in various cellular processes including cell differentiation. The effects of these activators are primarily exerted at the cellular level, targeting keratinocytes in the hair follicle, which is the site of KRTAP13-2 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of vitamin A, it regulates gene expression by activating nuclear receptors, potentially increasing the transcription of genes like KRTAP13-2 involved in keratinocyte differentiation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A catechin found in green tea, which can modulate signal transduction pathways, such as NF-kB, potentially affecting keratinocyte growth and differentiation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cAMP analog that can permeate cell membranes and activate protein kinase A (PKA), possibly leading to enhanced keratinocyte differentiation and upregulation of structural proteins like KRTAP13-2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
A diester of phorbol that acts as a protein kinase C (PKC) activator, which may lead to the alteration of keratinocyte differentiation pathways, indirectly affecting KRTAP13-2 expression. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A compound that increases intracellular calcium levels, which can influence keratinocyte differentiation and potentially the expression of keratin-associated proteins. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methylation inhibitor that can lead to the activation of silenced genes; it might indirectly upregulate the expression of KRTAP13-2 by altering the epigenetic state. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase, leading to increased levels of cAMP and activation of PKA, which could affect gene expression profiles in keratinocytes including KRTAP13-2. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
A histone deacetylase inhibitor that can lead to hyperacetylation of histones, resulting in an open chromatin structure and potentially increased transcription of differentiation-related genes. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $75.00 $120.00 | 8 | |
A synthetic retinoid that alters gene expression and is known to affect skin cell differentiation; it may play a role in the regulation of structural protein genes like KRTAP13-2. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
An essential vitamin that can influence collagen synthesis and might contribute to keratinocyte differentiation, thereby potentially impacting KRTAP13-2 expression. | ||||||