KOR-1 Activators
Items 1 to 10 of 17 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
U-69593 | 96744-75-1 | sc-203307 sc-203307A | 1 mg 5 mg | $87.00 $204.00 | 3 | |
U-69593 is a selective kappa-opioid receptor (KOR) agonist distinguished by its unique structural features that promote specific ligand-receptor interactions. Its hydrophobic regions enhance binding affinity, while the presence of multiple functional groups allows for intricate electrostatic interactions. This compound exhibits notable receptor selectivity, influencing downstream signaling cascades and modulating cellular responses through distinct allosteric effects within the KOR. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which can modulate integrin functions linked to CD151. | ||||||
BRL 52537 hydrochloride | 130497-33-5 | sc-202508 sc-202508A | 10 mg 50 mg | $208.00 $332.00 | ||
BRL 52537 hydrochloride is characterized by its unique ability to engage with kappa-opioid receptors (KOR) through a combination of steric and electronic properties. Its structural conformation facilitates specific hydrogen bonding and hydrophobic interactions, enhancing receptor affinity. The compound's dynamic behavior in solution allows for rapid conformational changes, influencing its interaction kinetics and promoting selective activation of intracellular signaling pathways associated with KOR. | ||||||
N-Methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]phenylacetamide hydrochloride | 207452-97-9 | sc-224143 | 1 mg | $200.00 | ||
N-Methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]phenylacetamide hydrochloride exhibits a distinctive binding profile with kappa-opioid receptors (KOR-1), driven by its intricate molecular architecture. The presence of a pyrrolidine ring introduces conformational flexibility, enabling effective π-π stacking and van der Waals interactions. This compound's solubility characteristics enhance its diffusion across biological membranes, facilitating nuanced receptor engagement and modulation of downstream signaling cascades. | ||||||
ADL5859 HCl | 850173-95-4 | sc-364396 sc-364396A | 5 mg 50 mg | $255.00 $1455.00 | ||
ADL5859 HCl is characterized by its unique structural features that promote selective interactions with kappa-opioid receptors (KOR-1). The compound's hydrophilic and lipophilic balance allows for efficient partitioning in various environments, enhancing its kinetic profile. Its ability to form hydrogen bonds and engage in hydrophobic interactions contributes to its specificity and affinity, influencing receptor conformational dynamics and subsequent signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This polyphenol can modulate cell adhesion and migration, potentially influencing CD151-mediated processes. | ||||||
U-62066 | 87151-85-7 | sc-253816 | 25 mg | $118.00 | ||
U-62066 exhibits distinctive reactivity as a KOR-1 ligand, showcasing a robust ability to form covalent bonds with receptor sites. Its unique steric configuration facilitates precise molecular docking, enhancing binding affinity. The compound's electronic properties promote charge transfer interactions, influencing the kinetics of receptor activation. Additionally, its solubility characteristics enable effective distribution in biological systems, impacting its overall pharmacodynamics. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By elevating cAMP levels, Forskolin can influence cellular signaling pathways that might intersect with CD151. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
This PI3K inhibitor can indirectly affect CD151 activity by altering integrin-linked kinase signaling. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
As a MEK inhibitor, U0126 may impact pathways involving CD151 through ERK/MAPK modulation. | ||||||