Molecular structure of U-62066, CAS Number: 87151-85-7
U-62066 (CAS 87151-85-7)
Alternate Names:
Spiradoline mesylate salt
Application:
U-62066 is a highly selective κ opioid receptor agonist as well as an antitussive
CAS Number:
87151-85-7
Molecular Weight:
521.50
Molecular Formula:
C22H30Cl2N2O2•CH4O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
U-62066 is a compound frequently used in research focusing on its binding affinity and action at opioid receptors. In studies pertaining to neuroscience, U-62066 is applied to investigate the modulation of neurotransmitter release and its subsequent effects on neural pathways. This compound is also of interest in examining the role of opioid receptors in the regulation of pain signaling pathways. Additionally, U-62066 is useful for researchers studying the mechanisms of addiction, as it provides a means to understand the complex interactions between neurotransmitter systems and behavior. In biochemistry, U-62066 is employed to study receptor-ligand interactions and to characterize the activation or inhibition of signal transduction processes.
U-62066 (CAS 87151-85-7) References
- Comparison of cardiovascular responses to intra-hippocampal mu, delta and kappa opioid agonists in spontaneously hypertensive rats and isolation-induced hypertensive rats. | Shen, S. and Ingenito, AJ. 1999. J Hypertens. 17: 497-505. PMID: 10404951
- Internalization of mu-opioid receptors in rat spinal cord slices. | Marvizón, JC., et al. 1999. Neuroreport. 10: 2329-34. PMID: 10439458
- Effects of a kappa agonist, spiradoline mesylate (U62,066E), on activation and vaginocervical-stimulation produced analgesia in rats. | Boyle, TJ., et al. 2001. Brain Res Bull. 54: 213-8. PMID: 11275411
- Kappa agonist-induced reduction in dopamine release: site of action and tolerance. | Donzanti, BA., et al. 1992. Res Commun Chem Pathol Pharmacol. 78: 193-210. PMID: 1282270
- Central monoaminergic mechanisms in mice and analgesic activity of spiradoline mesylate, a selective kappa-opioid receptor agonist. | Kunihara, M., et al. 1992. Eur J Pharmacol. 214: 111-8. PMID: 1325350
- Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid-induced inhibition of mirror-neuropathic pain in the rat. | Zhao, M., et al. 2007. Neuroscience. 144: 1486-94. PMID: 17184926
- Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain. | Wang, JY., et al. 2008. Neurochem Res. 33: 2134-41. PMID: 18473169
- Role of mu, delta and kappa opioid receptors in ethanol-reinforced operant responding in infant rats. | Miranda-Morales, RS., et al. 2012. Behav Brain Res. 234: 267-77. PMID: 22789403
- Analgesic activity of spiradoline mesylate (U-62,066E), a kappa opioid agonist in mice. | Kunihara, M., et al. 1989. Life Sci. 45: 1191-8. PMID: 2796604
- Quantitative analysis of effects of kappa-opioid agonists on postischemic hippocampal CA1 neuronal necrosis in gerbils. | Hall, ED. and Pazara, KE. 1988. Stroke. 19: 1008-12. PMID: 2840759
- Cardiovascular depressant effects of the kappa opioid receptor agonists U50488H and spiradoline mesylate. | Hall, ED., et al. 1988. Circ Shock. 26: 409-17. PMID: 2850873
- Effects of spiradoline mesylate, a selective kappa-opioid-receptor agonist, on the central dopamine system with relation to mouse locomotor activity and analgesia. | Kunihara, M., et al. 1993. Jpn J Pharmacol. 62: 223-30. PMID: 8411771
- New degradation product of spiradoline mesylate in aqueous solution: formation of an imidazolidine ring. | Ogata, M., et al. 1993. J Pharm Sci. 82: 91-4. PMID: 8429499
- Gender differences in kappa-opioid modulation of cocaine-induced behavior and NMDA-evoked dopamine release. | Sershen, H., et al. 1998. Brain Res. 801: 67-71. PMID: 9729284
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KOR-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U-62066, 25 mg | sc-253816 | 25 mg | $118.00 |