Date published: 2026-5-4

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BRL 52537 hydrochloride (CAS 130497-33-5)

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Application:
BRL 52537 hydrochloride is a selective κ/μ opioid receptor agonist
CAS Number:
130497-33-5
Molecular Weight:
391.8
Molecular Formula:
C18H24Cl2N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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BRL 52537 hydrochloride is a compound that functions as a selective and potent antagonist of the β3-adrenoceptor. It acts by binding to the β3-adrenoceptor and inhibiting its activation by endogenous ligands, thereby blocking the downstream signaling pathways associated with this receptor. Brl 52537 Hydrochloride targets the β3-adrenoceptor without significant affinity for other adrenoceptor subtypes, which may be useful for studying the physiological and pathological roles of the β3-adrenoceptor in various experimental models. By blocking the activation of the β3-adrenoceptor, BRL 52537 hydrochloride can modulate cellular responses and signaling pathways that are mediated by this receptor, providing insights into the molecular mechanisms underlying its function. In experimental applications, BRL 52537 hydrochloride can be used to investigate the involvement of the β3-adrenoceptor in various physiological processes its potential as a target in different states.


BRL 52537 hydrochloride (CAS 130497-33-5) References

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  2. Inhibition of cAMP accumulation by kappa-receptor activation in isolated iris-ciliary bodies: role of phosphodiesterase and protein kinase C.  |  Dortch-Carnes, J. and Potter, DE. 2002. J Pharmacol Exp Ther. 301: 599-604. PMID: 11961062
  3. Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats.  |  Goyagi, T., et al. 2003. Stroke. 34: 1533-8. PMID: 12738895
  4. Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats.  |  Zhang, Z., et al. 2003. Anesth Analg. 97: 1776-1783. PMID: 14633559
  5. Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats.  |  Chen, TY., et al. 2004. Stroke. 35: 1180-5. PMID: 15031456
  6. Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction.  |  Peart, JN., et al. 2004. J Cardiovasc Pharmacol. 43: 410-5. PMID: 15076225
  7. Ischemic neuroprotection with selective kappa-opioid receptor agonist is gender specific.  |  Chen, CH., et al. 2005. Stroke. 36: 1557-61. PMID: 15933260
  8. Cloning, heterologous expression and pharmacological characterization of a kappa opioid receptor from the brain of the rough-skinned newt, Taricha granulosa.  |  Bradford, CS., et al. 2005. J Mol Endocrinol. 34: 809-23. PMID: 15956349
  9. Neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide.  |  Zeynalov, E., et al. 2006. J Cereb Blood Flow Metab. 26: 414-20. PMID: 16049424
  10. Cardioprotective and antiarrhythmic effect of U50,488H in ischemia/reperfusion rat heart.  |  Cheng, L., et al. 2007. Heart Vessels. 22: 335-44. PMID: 17879026
  11. (2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics.  |  Vecchietti, V., et al. 1991. J Med Chem. 34: 397-403. PMID: 1846921
  12. The effect of kappa-opioid receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons.  |  Su, X., et al. 2009. Anesth Analg. 109: 632-40. PMID: 19608841
  13. Neuroprotection by the kappa-opioid receptor agonist, BRL52537, is mediated via up-regulating phosphorylated signal transducer and activator of transcription-3 in cerebral ischemia/reperfusion injury in rats.  |  Fang, S., et al. 2013. Neurochem Res. 38: 2305-12. PMID: 23996400
  14. Isobolographic Analysis of Drug Combinations With Intrathecal BRL52537 (κ-Opioid Agonist), Pregabalin (Calcium Channel Modulator), AF 353 (P2X3 Receptor Antagonist), and A804598 (P2X7 Receptor Antagonist) in Neuropathic Rats.  |  Jung, YH., et al. 2017. Anesth Analg. 125: 670-677. PMID: 28277328
  15. Role of opioid signaling in kidney damage during the development of salt-induced hypertension.  |  Golosova, D., et al. 2020. Life Sci Alliance. 3: PMID: 33046522

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

BRL 52537 hydrochloride, 10 mg

sc-202508
10 mg
$208.00

BRL 52537 hydrochloride, 50 mg

sc-202508A
50 mg
$332.00