Molecular structure of U-69593, CAS Number: 96744-75-1
U-69593 (CAS 96744-75-1)
See product citations (3)
Application:
U-69593 is a selective κ-opioid receptor agonist
CAS Number:
96744-75-1
Purity:
≥98%
Molecular Weight:
356.50
Molecular Formula:
C22H32N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
U69593 is a compound formed through the formal condensation of phenylacetic acid′s carboxy group with the secondary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine. This compound exhibits various properties, including being a kappa-opioid receptor agonist, an anti-inflammatory agent, and a diuretic. It falls under the category of an oxaspiro compound, specifically an N-alkylpyrrolidine, and can be classified as an organic heterobicyclic compound as well as a monocarboxylic acid amide.
U-69593 (CAS 96744-75-1) References
- The kappa-opioid agonist, U-69593, decreases acute amphetamine-evoked behaviors and calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum. | Gray, AM., et al. 1999. J Neurochem. 73: 1066-74. PMID: 10461896
- Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. | Thompson, AC., et al. 2000. J Neurosci. 20: 9333-40. PMID: 11125013
- The kappa-opioid agonist U-69593 affects intracellular calcium level in R1.1 mouse thymoma cell line. | Martin-Kleiner, I. and Gabrilovac, J. 2002. Int Immunopharmacol. 2: 975-80. PMID: 12188038
- The effect of opioid agonists of delta-class DSLET, mu-class DAMGO, kappa-class U-69593 and an opioid antagonist, naloxone, on MTT activity of NALM-1 leukemic cells. | Martin-Kleiner, I. 2002. Biomed Pharmacother. 56: 458-62. PMID: 12481982
- Repeated administration of the selective kappa-opioid receptor agonist U-69593 increases stimulated dopamine extracellular levels in the rat nucleus accumbens. | Fuentealba, JA., et al. 2006. J Neurosci Res. 84: 450-9. PMID: 16676328
- The kappa-opioid receptor agonist U-69593 prevents cocaine-induced phosphorylation of DARPP-32 at Thr(34) in the rat brain. | D'Addario, C., et al. 2007. Brain Res Bull. 73: 34-9. PMID: 17499634
- Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593. | Fuentealba, JA., et al. 2007. Synapse. 61: 771-7. PMID: 17568430
- U-69593, a kappa opioid receptor agonist, decreases cocaine-induced behavioral sensitization in female rats. | Puig-Ramos, A., et al. 2008. Behav Neurosci. 122: 151-60. PMID: 18298258
- Depletion of serotonin decreases the effects of the kappa-opioid receptor agonist U-69593 on cocaine-stimulated activity. | Zakharova, E., et al. 2008. Eur J Pharmacol. 586: 123-9. PMID: 18395712
- Activation of micro, delta or kappa opioid receptors by DAMGO, DPDPE, U-50488 or U-69593 respectively causes antinociception in the formalin test in the naked mole-rat (Heterocephalus glaber). | Towett, PK., et al. 2009. Pharmacol Biochem Behav. 91: 566-72. PMID: 18929596
- Repeated treatment with the κ-opioid agonist U-69593 increases K+-stimulated dopamine release in the rat medial prefrontal cortex. | Fuentealba, JA., et al. 2010. Synapse. 64: 898-904. PMID: 20939060
- Analysis of the Illicit Opioid U-48800 and Related Compounds by LC-MS-MS and Case Series of Fatalities Involving U-48800. | Fogarty, MF., et al. 2022. J Anal Toxicol. 46: 17-24. PMID: 33237987
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KOR-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U-69593, 1 mg | sc-203307 | 1 mg | $85.00 | |||
U-69593, 5 mg | sc-203307A | 5 mg | $200.00 |