KLKb11 Activators
KLKb11, belonging to the kallikrein-related peptidase family, plays a pivotal role in various biological processes through its proteolytic activity. The regulation of its expression is a complex interplay between multiple cellular signaling pathways and transcriptional mechanisms, making it a focal point for understanding cellular dynamics in response to different stimuli. The expression of KLKb11 can be influenced by a wide range of compounds, each acting through distinct molecular mechanisms to enhance the transcription and subsequent protein synthesis. These compounds, often referred to as activators, can be endogenous or exogenous, with some having the capability to cross cell membranes and interact directly with intracellular components to elicit a biological response leading to the upregulation of KLKb11.
Activators such as Dexamethasone and Hydrocortisone, classified as glucocorticoids, can bind to specific receptor sites and initiate a signaling cascade that results in the translocation of the receptor-ligand complex to the nucleus. Within the nucleus, these complexes can interact with glucocorticoid response elements in the promoter regions of target genes, such as KLKb11, to induce transcription. Similarly, compounds like Phorbol 12-myristate 13-acetate (PMA) are known to activate protein kinase C (PKC), which subsequently can enhance the transcription of genes involved in inflammatory responses, which may include KLKb11. Furthermore, Forskolin's ability to increase intracellular cAMP levels leads to the activation of cAMP response element-binding protein (CREB), a transcription factor that can stimulate the transcription of a plethora of genes. Another layer of control is exerted epigenetically by compounds such as Sodium butyrate and Trichostatin A, which can modify chromatin structure, making the genomic DNA more accessible for transcriptional machinery and thus potentially increasing the expression levels of KLKb11. Each of these activators operates through a unique pathway, reflecting the diverse regulatory network that governs the expression of KLKb11, highlighting the intricate balance within cellular environments that determines the expression patterns of key proteases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
This glucocorticoid may initiate transcription of Klk1b11 by binding to glucocorticoid response elements within the gene's promoter, thereby promoting gene activity specifically in response to inflammatory stimuli. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA can directly activate protein kinase C, which in turn triggers a cascade that culminates in the heightened transcription of Klk1b11, likely through activation of AP-1 transcription factor that binds to the promoter region of genes involved in inflammation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can activate its corresponding nuclear receptors which, upon binding to retinoic acid response elements, can stimulate the transcription of target genes including Klk1b11, often involved in differentiation and inflammation pathways. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $70.00 $281.00 $536.00 $1076.00 $2142.00 | 3 | |
By binding to estrogen receptors, diethylstilbestrol can trigger a signaling cascade resulting in the transcriptional initiation of genes like Klk1b11, presuming the presence of estrogen response elements in the gene's upstream regulatory regions. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
This inhibitor may promote the acetylation of histones associated with the Klk1b11 gene, reducing chromosomal compaction and making the gene more accessible for transcriptional machinery, thereby boosting the gene's expression levels. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP, which activates CREB, a transcription factor that binds to cAMP response elements, potentially stimulating the transcription of Klk1b11 by enhancing the assembly of transcriptional complexes at the gene's promoter. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit GSK-3, which may lead to the stabilization and activation of transcription factors that drive the expression of Klk1b11, thus potentially resulting in an upsurge of the protein under certain cellular conditions. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A can lead to the hyperacetylation of histones at the Klk1b11 gene locus, thereby reducing nucleosomal repression and fostering an environment conducive to transcriptional activation, leading to an upsurge in Klk1b11 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol can bind to and activate estrogen receptors, which may then engage with estrogen response elements in the Klk1b11 gene promoter, resulting in the transcriptional activation and subsequent increase in the gene's expression. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
As a precursor in the synthesis of prostaglandins and leukotrienes, arachidonic acid can prompt the transcription of genes involved in the inflammatory response, potentially including Klk1b11, by stimulating nuclear receptors and transcription factors. | ||||||