KIAA1731 Activators
KIAA1731, central in microtubule binding activity and centriole replication, has a range of activators extrapolated from a profound grasp of cellular pathways. Insulin, by modulating the PI3K/Akt pathway, exerts a profound impact on cellular growth and metabolism. Considering KIAA1731's pivotal role in microtubule dynamics, the cascading effects of insulin's regulation can extend its reach to this protein, establishing a nexus between metabolic pathways and structural proteins.
Similarly, epigenetic regulators such as sodium butyrate and 5-Azacytidine elucidate the intricate dance between gene expression and protein function. By sculpting the epigenetic milieu, these compounds introduce avenues for KIAA1731 modulation, emphasizing its integral role in microtubule activity and centriole replication. In juxtaposition, agents like curcumin and EGCG come to the fore, with their adeptness at directing the NF-kB and AMPK pathways, respectively. The resultant cellular modulations, be it in energy homeostasis or gene expression dynamics, craft an environment conducive for KIAA1731's enhanced or diversified activity. On another front, compounds like nocodazole, colchicine, and vinblastine that engage directly with microtubule dynamics pose thought-provoking scenarios. By altering the very structures KIAA1731 associates with, these compounds could pave the way for cellular counter-responses, elevating or adjusting KIAA1731's role. This intricate interplay of pathways, agents, and KIAA1731 underscores the multifaceted nature of cellular function and regulation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Stimulates the PI3K/Akt pathway, which governs cellular growth and metabolism. This can influence proteins involved in microtubule dynamics, including KIAA1731. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates NF-kB pathway, potentially affecting gene expression and protein function dynamics, including those like KIAA1731 associated with microtubule activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Influences gene expression by acting as a ligand for nuclear receptors. May indirectly modulate KIAA1731 through gene expression controls, particularly those linked to microtubule assembly. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Activates AMPK pathway which regulates cellular energy homeostasis. Through this regulation, proteins involved in cellular structures, like KIAA1731, can be indirectly influenced. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Another activator of the AMPK pathway, it holds potential to indirectly affect KIAA1731's function in centriole replication by influencing cellular energy dynamics. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Has epigenetic influence, specifically as a histone deacetylase (HDAC) inhibitor. By altering gene expression, it may affect the microtubule binding activity of KIAA1731. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Acts as a DNA methyltransferase inhibitor, impacting gene expression. Its influence on the cellular epigenetic landscape can modify the activity of proteins like KIAA1731. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences the Wnt/beta-catenin pathway. While the direct link to KIAA1731 remains under-explored, any structural cellular changes can potentially modify its function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Affects microtubule dynamics by disrupting their polymerization. The resultant cellular response to stabilize microtubules might indirectly activate KIAA1731 functions. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Induces DNA damage, leading to cellular response mechanisms that involve structural proteins and repair systems. KIAA1731, being part of the microtubule network, may be influenced. | ||||||