KIAA1467 Inhibitors
Direct inhibitors of KIAA1467 interact directly with the protein and reduce its expression or activity. These include chemicals that can block the binding of KIAA1467 to its binding partners, reduce the transcription of the KIAA1467 gene, or promote the degradation of the KIAA1467 protein. Examples of direct inhibitors include ICG-003, Chirality-corrected Cyclosporin A (CSA), and SMI-16a. SMI-16a promotes the interaction between Dishevelled and AXIN proteins, leading to decreased β-catenin stabilization and suppression of KIAA1467 expression.
Indirect inhibitors of KIAA1467 do not directly interact with the protein but instead act on upstream signaling pathways or cellular processes that can influence KIAA1467 expression or degradation. These include chemicals that can activate or inhibit signaling pathways, modulate protein stability or degradation, or alter cellular processes such as oxidative stress or inflammation. Examples of indirect inhibitors include, Phorbol 12-myristate-13-acetate (PMA), Tumor necrosis factor-alpha (TNF-α), and Interleukin-1α (IL-1α). TB509 generates reactive oxygen species (ROS) and activates oxidative stress signaling pathways, promoting KIAA1467 degradation. PMA activates PKC, a signaling molecule that promotes KIAA1467 degradation through phosphorylation-mediated proteasomal targeting. TNF-α and IL-1α induce NF-κB activation, leading to increased KIAA1467 expression. Inhibiting TNF-α and IL-α can indirectly suppress KIAA1467 expression.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
A specific Akt inhibitor. By inhibiting Akt, it can alter downstream signaling events in pathways potentially involving KIAA1467, leading to its reduced activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK (c-Jun N-terminal kinase), which is involved in stress and inflammatory responses. Inhibition of JNK can modify signaling cascades that intersect with KIAA1467's function, leading to its decreased activity. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
A multi-kinase inhibitor that targets RAF kinases. By inhibiting these kinases, Sorafenib can modulate the MAPK/ERK pathway, potentially reducing KIAA1467 activity through interconnected signaling networks. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A Src family kinase inhibitor. Src kinases are involved in various signaling pathways; inhibiting them can indirectly downregulate KIAA1467 activity through altered cellular signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, which can influence the PI3K/Akt pathway. Inhibiting PI3K can lead to downstream effects that indirectly decrease KIAA1467 activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor, affecting the degradation of proteins involved in cell cycle regulation. This can indirectly influence KIAA1467 activity by altering the cellular protein balance. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
An EGFR inhibitor. By blocking EGFR signaling, Gefitinib can indirectly decrease KIAA1467 activity through modulation of related signaling pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor. Inhibiting mTOR can lead to changes in cell growth and proliferation pathways, potentially decreasing KIAA1467 activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
A Bcr-Abl and Src family kinase inhibitor. Dasatinib's action on these kinases can lead to altered signaling pathways, potentially reducing KIAA1467 activity. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
A tyrosine kinase inhibitor, particularly targeting Bcr-Abl, c-Kit, and PDGFR. By modulating these kinases, Imatinib can influence signaling networks involving KIAA1467, reducing its activity. | ||||||