KIAA1239 Activators
KIAA1239 Activators consist of a diverse array of chemical compounds that serve to indirectly promote the functional activity of KIAA1239 by influencing various signaling pathways. Forskolin, with its ability to stimulate adenylyl cyclase, raises intracellular cAMP levels and subsequently activates PKA. This kinase is known to phosphorylate numerous proteins, potentially including KIAA1239, thus enhancing its activity. IBMX, by inhibiting cAMP degradation, maintains PKA activity at a heightened state, which may similarly augment the functional capacity of KIAA1239. PMA, through the activation of PKC, and sphingosine-1-phosphate, by initiating cytoskeletal reorganization signals, can indirectly modify the activity of KIAA1239, potentially increasing its role in cellular adhesion or migration. Furthermore, Thapsigargin's disruption of calcium homeostasis can lead to the activation of calcium-dependent kinases, which might influence KIAA1239 activity through phosphorylation-dependent mechanisms.
The PI3K inhibitor LY294002 and the MEK inhibitors U0126 and PD98059 manipulate intracellular signaling networks, potentially resulting in a compensatoryenhancement of pathways that could activate KIAA1239. Inhibition of MEK with U0126 and PD98059 may lead to the activation of alternative pathways that could favor KIAA1239's functional roles. Similarly, the inhibition of protein phosphatases by Calyculin A and Okadaic acid prompts an increase in phosphorylation levels of proteins within the cell, which could include the phosphorylation and subsequent activation of KIAA1239. Staurosporine, though broadly targeting protein kinases, might paradoxically enhance KIAA1239 activity by selectively inhibiting kinases that normally suppress KIAA1239-involved pathways. Additionally, EGCG's inhibition of multiple protein kinases may lead to a reconfiguration of cellular signaling that indirectly upregulates KIAA1239's activity, illustrating how these activators collectively contribute to the regulation of KIAA1239 without directly increasing its expression or initiating its inherent activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and enhance the functional activity of KIAA1239. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes responsible for the breakdown of cAMP. By preventing cAMP degradation, IBMX indirectly sustains PKA activity, which is known to phosphorylate substrates, thereby potentially enhancing the activity of KIAA1239. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC) which can modulate the phosphorylation status of numerous proteins. PKC-mediated signaling pathways may influence KIAA1239's activity by altering its phosphorylation state. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate engages with its receptors, initiating signaling cascades that can lead to actin cytoskeletal rearrangements. This signaling can indirectly affect KIAA1239's role in cell adhesion and migration. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). Elevated cytosolic calcium levels can activate calcium-dependent protein kinases, potentially influencing KIAA1239's activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, which upon inhibition can cause a compensatory response in other signaling pathways, potentially enhancing those that lead to the activation of KIAA1239. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, leading to decreased ERK1/2 signaling. This modulation may cause a feedback response that enhances alternative pathways, possibly including those that activate KIAA1239. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which could lead to compensatory activation of other signaling cascades that might enhance KIAA1239's activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of cellular proteins. This can lead to the enhancement of KIAA1239's activity if it is regulated by phosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a selective inhibitor of protein phosphatases 1 and 2A, which results in increased phosphorylation of cellular proteins, similarly to Calyculin A, and could enhance KIAA1239's activity. | ||||||