KIAA1009 Inhibitors
Chemical inhibitors of KIAA1009 include a range of compounds that indirectly affect the protein's function by targeting cellular structures and processes essential for its activity. Monastrol, a known inhibitor of the kinesin Eg5, disrupts the formation of spindle bipolarity, which is crucial for the proper function of the centrosome and mitotic spindle structures. Similarly, S-Trityl-L-cysteine selectively inhibits Eg5, leading to defects in spindle assembly, thereby influencing KIAA1009's role in centrosome stability. Another Eg5 inhibitor, Dimethylenastron, compromises centrosome-associated spindle apparatus functionality, thereby affecting KIAA1009. Ispinesib, by selectively inhibiting kinesin spindle protein (KSP), undermines the integrity of spindle assembly, which is essential for the role KIAA1009 plays in centrosome function.
Moreover, chemicals like Nocodazole and Vinblastine work by destabilizing microtubules, which are critical for centrosome and spindle function, thus interfering with KIAA1009's activity. In contrast, Paclitaxel (Taxol) stabilizes microtubules to such an extent that it impedes the dynamic instability necessary for KIAA1009's function. Colchicine, by preventing tubulin polymerization, disrupts the microtubule organization and mitotic spindle function, indirectly affecting KIAA1009's associated processes. Purvalanol A, an inhibitor of cyclin-dependent kinases (CDKs), disrupts CDK-dependent phosphorylation processes crucial for centrosome duplication and spindle assembly, thereby affecting KIAA1009's function. ZM447439 and BI 2536 target Aurora kinase and Polo-like kinase 1 (Plk1), respectively, both of which are essential for centrosome maturation and function. Their inhibition results in the disruption of centrosome cycles and spindle assembly mechanisms, impacting KIAA1009's activity. Lastly, Maribavir, though primarily known for targeting viral kinases, also inhibits cellular kinases that can affect the phosphorylation state of proteins involved in centrosome function, which is a key aspect of KIAA1009's role within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a cell-permeable small molecule inhibitor of the mitotic kinesin Eg5 which plays a key role in spindle bipolarity. Inhibition of Eg5 disturbs spindle pole separation, which can indirectly inhibit KIAA1009 by preventing the proper formation of the centrosome and mitotic spindle structures that KIAA1009 is associated with. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
S-Trityl-L-cysteine is a selective inhibitor of Eg5, a kinesin-related motor protein. By specifically inhibiting Eg5, this chemical disrupts the function of the mitotic spindle, which is crucial for centrosome dynamics and function, thus indirectly inhibiting KIAA1009's role in centrosome stability and spindle assembly. | ||||||
Eg5 Inhibitor III, Dimethylenastron | 863774-58-7 | sc-221576 sc-221576A sc-221576B sc-221576C | 1 mg 5 mg 10 mg 25 mg | $38.00 $132.00 $244.00 $516.00 | 1 | |
Dimethylenastron is an inhibitor of kinesin Eg5. It disrupts the mitotic spindle function by preventing the proper operation of Eg5, and thus can indirectly inhibit KIAA1009 by disrupting the centrosome and spindle apparatus with which it is associated. | ||||||
Ispinesib | 336113-53-2 | sc-364747 | 10 mg | $495.00 | ||
Ispinesib selectively inhibits kinesin spindle protein (KSP), another kinesin motor protein involved in spindle formation during cell division. By inhibiting KSP, ispinesib indirectly inhibits KIAA1009 by compromising the integrity of the spindle assembly and thus centrosome function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a synthetic molecule that acts as a microtubule destabilizer. By disrupting the microtubule network, nocodazole can indirectly inhibit KIAA1009 by interfering with the centrosome's ability to nucleate microtubules, which is essential for its function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel is a microtubule stabilizer that binds to β-tubulin and enhances tubulin polymerization, leading to microtubule stabilization and interference with mitotic spindle function. As KIAA1009 is involved in centrosome and spindle dynamics, paclitaxel can indirectly inhibit KIAA1009 by disrupting the dynamic instability required for its function. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule formation. This action on the microtubule dynamics can indirectly inhibit KIAA1009 by preventing the proper assembly and function of the centrosome and mitotic spindle. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules, thereby disrupting mitotic spindle function and microtubule organization. This can indirectly inhibit KIAA1009's function related to the centrosome and spindle apparatus. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a potent CDK inhibitor. It can indirectly inhibit KIAA1009 by disrupting CDK-dependent phosphorylation processes that are essential for the regulation of centrosome duplication and spindle assembly, where KIAA1009 is involved. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor. Aurora kinases are critical for centrosome maturation and separation, and their inhibition can indirectly inhibit KIAA1009 by disrupting the centrosome cycle and spindle assembly mechanisms. | ||||||