Keratin 72 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is a cyclic peptide found in a fungus. It acts as an immunosuppressant by inhibiting the activity of calcineurin, a phosphatase enzyme involved in T-cell activation. While there is no direct evidence of Cyclosporin A inhibiting Keratin 72, it can potentially indirectly inhibit its expression by suppressing the immune response and reducing the activation of T-cells, which play a role in keratinocyte differentiation and proliferation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β inhibitors, such as SB 431542, can block the activity of the transforming growth factor-beta (TGF-β) signaling pathway. TGF-β is involved in regulating various cellular processes, including epithelial-mesenchymal transition (EMT) and keratinocyte differentiation. By inhibiting the TGF-β pathway, these inhibitors can potentially affect the expression and function of Keratin 72. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
PKC inhibitors, such as Bisindolylmaleimide I (GF 109203X), can inhibit the activity of protein kinase C, a family of serine/threonine kinases involved in various cellular processes, including keratinocyte differentiation. By inhibiting PKC, these inhibitors can potentially affect the signaling pathways that regulate Keratin 72 expression and function. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
Calcium chelators, such as EGTA, can sequester calcium ions and disrupt calcium-dependent signaling pathways. Calcium plays a crucial role in keratinocyte differentiation and the expression of keratins. By chelating calcium, these inhibitors can potentially disrupt the signaling pathways involved in Keratin 72 expression and function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family. JNK is involved in various cellular processes, including keratinocyte differentiation. By inhibiting JNK, SP600125 can potentially affect the signaling pathways that regulate Keratin 72 expression and function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of extracellular signal-regulated kinase (ERK), another member of the MAPK family. ERK is involved in cell proliferation and differentiation, including keratinocyte differentiation. By inhibiting ERK, U0126 can potentially influence the expression and function of Keratin 72. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H89 is a selective inhibitor of protein kinase A (PKA), a serine/threonine kinase involved in various cellular processes, including keratinocyte differentiation. By inhibiting PKA, H89 can potentially affect the signaling pathways that regulate Keratin 72 expression and function. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an inhibitor of nuclear factor-kappa B (NF-κB), a transcription factor involved in inflammation and cell survival. NF-κB signaling pathways can influence keratinocyte differentiation and the expression of keratins. By inhibiting NF-κB, BAY 11-7082 can potentially affect the expression and function of Keratin 72. | ||||||
KT5823 | 126643-37-6 | sc-3534 sc-3534A sc-3534B | 100 µg 1 mg 5 mg | $178.00 $1204.00 $4799.00 | 21 | |
KT5823 is a selective inhibitor of protein kinase G (PKG), a serine/threonine kinase involved in cellular signaling pathways. PKG can regulate keratinocyte differentiation and the expression of keratins. By inhibiting PKG, KT5823 can potentially influence the expression and function of Keratin 72. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a potent inhibitor of histone deacetylases (HDACs), enzymes that remove acetyl groups from histone proteins, affecting gene expression. HDAC inhibitors can modulate the expression of genes involved in keratinocyte differentiation, potentially affecting the expression of Keratin 72. | ||||||