Keratin 33A Inhibitors
Keratin 33A inhibitor retinoic acid can modulate the expression of genes, including those for keratins, by activating nuclear receptors which leads to transcriptional changes. Spironolactone, while principally an aldosterone antagonist, can have cascading effects on cellular ion balance that indirectly affect protein expression and stability.
Inhibitors like lithium chloride target pathways such as the Wnt signaling cascade and can have downstream effects on the organization of the cytoskeleton, of which keratins are integral components. Imatinib mesylate, a tyrosine kinase inhibitor, affects cellular kinases that are involved in regulating the dynamics of the cytoskeleton. Modulating the cytoskeletal dynamics can, in turn, influence the assembly of keratin proteins. The inclusion of agents that affect protein synthesis and turnover, such as cycloheximide and rapamycin, is based on the premise that these processes are essential for the maintenance of cellular protein levels, including keratins. Methotrexate and 5-fluorouracil disrupt nucleotide synthesis and thereby can alter the proliferation and differentiation of cells, which can lead to changes in keratin expression. Compounds like EGCG and caffeine, known for their broad effects on cellular signaling including inflammation and the cell cycle, can also affect the homeostasis of keratin proteins within the cell.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
Aldosterone antagonist that can alter cellular ion balance and indirectly affect protein expression and stability, including keratins. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of vitamin A that modulates gene expression and can induce keratin gene expression changes. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
GSK-3 inhibitor that can alter Wnt signaling, potentially affecting keratin expression and cytoskeletal organization. | ||||||
Imatinib mesylate | 220127-57-1 | sc-202180 sc-202180A | 25 mg 100 mg | $45.00 $111.00 | 61 | |
Tyrosine kinase inhibitor that affects ABL kinases, which can modulate cytoskeletal dynamics and potentially influence keratin assembly. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Adenosine receptor antagonist that can modulate cell cycle and growth signaling pathways, which may impact keratin turnover. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Antimetabolite that disrupts RNA and DNA synthesis, affecting cell proliferation and potentially influencing keratin expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibits protein synthesis, which may lead to decreased expression of keratins. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Polyphenol can modulate multiple pathways, including those related to inflammation and oxidative stress, potentially affecting keratin expression and function. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
Solvent that can permeabilize cells and affect protein conformation and function, possibly influencing keratin assembly. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Dihydrofolate reductase inhibitor that disrupts nucleotide synthesis and can alter cell proliferation and differentiation, affecting keratin levels. | ||||||