Keratin 28 Activators
Keratin 28 Activators are a class of chemical compounds that enhance the functional activity of Keratin 28, a protein that is part of the keratin family and is involved in the formation of the intermediate filament structure of epithelial cells. Some Keratin 28 activators, such as retinoic acid, tazarotene, isotretinoin, acitretin, and tretinoin, bind to retinoic acid receptors, promoting signaling cascades that lead to the enhanced functional activity of Keratin 28. This process exemplifies how specific nuclear receptors can be targeted to increase the functional activity of Keratin 28.
Other Keratin 28 activators act through different mechanisms, but all lead to the promotion of keratinocyte differentiation and the upregulation of Keratin 28. Calcipotriol and calcitriol, analogs and active forms of vitamin D respectively, bind to the vitamin D receptor in keratinocytes, leading to the increased expression of keratinocyte differentiation markers, including Keratin 28. Glycolic acid, salicylic acid, and lactic acid promote keratinocyte differentiation by exfoliating the skin, which can lead to the upregulation of Keratin 28. Methotrexate and 5-Fluorouracil indirectly promote keratinocyte differentiation by inhibiting enzymes involved in DNA synthesis, leading to slowed proliferation and enhanced differentiation of keratinocytes, increasing the functional activity of Keratin 28.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can lead to the upregulation of keratinocyte differentiation, including the expression of Keratin 28. It binds to retinoic acid receptors that can activate signaling cascades, leading to the enhanced functional activity of Keratin 28. | ||||||
Calcipotriol | 112965-21-6 | sc-203537 sc-203537A | 10 mg 50 mg | $199.00 $816.00 | 4 | |
Calcipotriol, a vitamin D analog, binds to the vitamin D receptor in keratinocytes, increasing the expression of keratinocyte differentiation markers, including Keratin 28. | ||||||
Tazarotene | 118292-40-3 | sc-220193 | 10 mg | $103.00 | ||
Tazarotene is a synthetic retinoid prodrug that is converted to its active form, tazarotenic acid, in the skin. It binds to retinoic acid receptors, promoting keratinocyte differentiation and the enhanced function of Keratin 28. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $74.00 $118.00 | 8 | |
Isotretinoin is a retinoid that promotes keratinocyte differentiation. It binds to retinoic acid receptors, promoting cascades that enhance the functional activity of Keratin 28. | ||||||
Acitretin | 55079-83-9 | sc-210754 | 25 mg | $148.00 | 1 | |
Acitretin is an oral retinoid that promotes keratinocyte differentiation. It binds to retinoic acid receptors, enhancing the function of Keratin 28. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate indirectly promotes keratinocyte differentiation by inhibiting dihydrofolate reductase, an enzyme involved in DNA synthesis. This action can lead to slowed proliferation and enhanced differentiation of keratinocytes, increasing the functional activity of Keratin 28. | ||||||
Glycolic acid solution | 79-14-1 | sc-215102 sc-215102A | 25 g 500 g | $38.00 $60.00 | ||
Glycolic acid promotes keratinocyte differentiation by exfoliating the skin, which can lead to the upregulation of Keratin 28. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylic acid is a beta hydroxy acid that promotes keratinocyte differentiation by exfoliating the skin, which can lead to the upregulation and enhanced functional activity of Keratin 28. | ||||||
Lactic acid | 50-21-5 | sc-215227 sc-215227A | 100 ml 500 ml | $100.00 $175.00 | 1 | |
Lactic acid promotes keratinocyte differentiation by exfoliating the skin, which can lead to the upregulation and enhanced functional activity of Keratin 28. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
Calcitriol, the active form of vitamin D, binds to the vitamin D receptor in keratinocytes, increasing the expression of keratinocyte differentiation markers, including Keratin 28. | ||||||