KDEL receptor 3 Activators
KDEL receptor 3 Activators are a set of chemical compounds that indirectly stimulate the functional activity of KDEL receptor 3 by modulating various cellular processes and signaling pathways. Cyclopiazonic Acid serves as SERCA pump inhibitor, leading to an increased cytosolic calcium concentration, which then enhances KDEL receptor 3's affinity for KDEL sequence-containing proteins, thereby facilitating their retrograde transport from the Golgi to the endoplasmic reticulum. Nigericin, as a K+/H+ ionophore, alters intracellular pH and ion gradients, particularly affecting the Golgi, which in turn can promote the KDEL receptor 3-mediated binding and retrieval of proteins.
Ionomycin and A23187, both calcium ionophores, directly elevate intracellular calcium levels, thus stimulating KDEL receptor 3 by increasing its protein binding efficiency for retrieval to the endoplasmic reticulum. Dithiothreitol, by affecting disulfide bond formation and thus protein folding, and EGTA, through calcium chelation, induce cellular mechanisms that ultimately lead to an enhanced role for KDEL receptor 3 in maintaining protein and calcium homeostasis within the ER. These activators, through their targeted effects on specific cellular functions, collectively enhance the operational efficiency of KDEL receptor 3 without upregulating its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic Acid is an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA). Inhibition of SERCA leads to an increase in cytosolic calcium concentrations, which can enhance the retrieval function of the KDEL receptor 3 by increasing its affinity for KDEL sequence-containing proteins in the Golgi apparatus, thus promoting the retrograde transport to the endoplasmic reticulum. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels by transporting Ca2+ across membranes. Elevated calcium levels can enhance KDEL receptor 3 activity by increasing its affinity for KDEL-tagged proteins, facilitating their retrograde transport to the endoplasmic reticulum. | ||||||
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $46.00 $112.00 $240.00 $7079.00 $27417.00 | 9 | |
Nigericin is a K+/H+ ionophore that affects the pH and ion gradients across cellular compartments. Alteration of these gradients, particularly in the Golgi, can enhance KDEL receptor 3 function by modulating its cargo binding and release mechanisms during the transport cycle. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium concentration. This elevation in Ca2+ can enhance the function of KDEL receptor 3 by promoting the binding of KDEL sequence-containing proteins, which are then preferentially retrieved from the Golgi and returned to the endoplasmic reticulum. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
EGTA is a calcium chelator that depletes available calcium in the cell. While this might seem counterintuitive, a temporary decrease in calcium can trigger homeostatic mechanisms that compensate by enhancing KDEL receptor 3 activity to restore calcium levels through its role in the retrieval and recycling of calcium-binding proteins within the ER. | ||||||