KCNT1 Activators
Quinidine, traditionally viewed as an antiarrhythmic due to its sodium channel blockage, exerts an inhibitory action on KCNT1 channels, which results in an atypical activation effect under specific conditions. Muscle relaxant Chlorzoxazone, on the other hand, directly activates KCNT1, leading to a boost in channel activity. In a similar vein, Riluzole, recognized for its neuroprotective effects, promotes the surface expression of KCNT1, thereby increasing channel activity.
Calcium channel blocker Bepridil and antifungal Ciclopirox both share the ability to activate KCNT1 channels, albeit via different binding interactions, resulting in increased potassium conductance. Bithionol, another activator, also modulates potassium ion flow through KCNT1 activation. Haloperidol activates KCNT1, which implicates potassium ion efflux. Anthelmintic agents like Niclosamide, by enhancing KCNT1 channel activation, impact the movement of potassium ions, an effect shared by the paradoxical activator Clofilium Tosylate. Diuretic Ethacrynic Acid's interaction with KCNT1 leads to a modulation of potassium transport, a function similarly altered by the NSAID Diclofenac through its activation of KCNT1 channels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quinidine | 56-54-2 | sc-212614 | 10 g | $104.00 | 3 | |
Quinidine is a class I antiarrhythmic agent that can block voltage-gated sodium channels. It also has been found to inhibit KCNT1 channels. | ||||||
Chlorzoxazone | 95-25-0 | sc-211078 | 10 mg | $62.00 | ||
Chlorzoxazone is a muscle relaxant that can activate KCNT1 channels, leading to an increase in their activity. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $193.00 $213.00 $317.00 | 1 | |
Riluzole, primarily known for its neuroprotective properties, can enhance the surface expression of KCNT1 channels, thereby increasing their activity. | ||||||
Bepridil | 64706-54-3 | sc-507400 | 100 mg | $1620.00 | ||
Bepridil is a calcium channel blocker that can also activate KCNT1 channels, contributing to increased potassium ion conductance. | ||||||
Bithionol | 97-18-7 | sc-239383 | 25 g | $79.00 | ||
Bithionol, an anthelmintic compound, can activate KCNT1 channels, thus modulating potassium ion flow across the membrane. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $27.00 $79.00 $154.00 $309.00 | 1 | |
Flufenamic Acid is a nonsteroidal anti-inflammatory drug that can activate KCNT1 channels, leading to changes in cellular excitability. | ||||||
Ciclopirox | 29342-05-0 | sc-217893 | 25 mg | $207.00 | 2 | |
Ciclopirox is an antifungal agent that can elevate KCNT1 activity, impacting potassium ion transport. | ||||||
Haloperidol | 52-86-8 | sc-507512 | 5 g | $190.00 | ||
Haloperidol can activate KCNT1 channels, affecting neuronal excitability and potassium ion efflux. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide is an anthelmintic medication that can enhance KCNT1 channel activation, influencing ion conductance. | ||||||
Clofilium tosylate | 92953-10-1 | sc-391228 sc-391228A | 25 mg 100 mg | $437.00 $1040.00 | 1 | |
Clofilium Tosylate is a potassium channel blocker that can paradoxically activate KCNT1 channels at certain concentrations. | ||||||