KChIP4 Activators
The chemicals that can be classified as KChIP4 activators would primarily function through the modulation of intracellular calcium levels or the cAMP signaling pathway. Calcium dynamics are a central aspect of the activity of KChIP4, as it is a calcium-binding protein. Chemicals that alter calcium homeostasis, such as calcium channel blockers and ionophores, can thereby indirectly influence the function of KChIP4 by altering its calcium-dependent interactions. For example, nifedipine and isradipine, by blocking voltage-dependent L-type calcium channels, could increase the cytosolic calcium concentration, which may enhance the interaction of KChIP4 with its potassium channel targets.
Additionally, signaling molecules that modulate cAMP levels, such as forskolin, which activates adenylate cyclase, and phosphodiesterase inhibitors, could also affect KChIP4 function. Increased cAMP can lead to the activation of protein kinase A (PKA), which may phosphorylate target proteins and influence the interaction of KChIP4 with potassium channels.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
A calcium channel blocker that can indirectly increase cellular calcium, possibly leading to increased interaction of KChIP4 with its targets. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $88.00 $324.00 | 1 | |
Another calcium channel blocker that could similarly alter calcium dynamics and thus modulate KChIP4 activity. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
A calcium channel agonist that could enhance calcium entry, potentially affecting KChIP4's modulation of potassium channels. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase which can raise intracellular cAMP levels, potentially influencing KChIP4 activity via PKA phosphorylation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cAMP analog that could mimic the effect of forskolin and modulate KChIP4 indirectly. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that increases intracellular calcium concentration, potentially influencing KChIP4. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
An inhibitor of the ER calcium ATPase, raising cytosolic calcium levels, which could affect KChIP4 function. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
A calcium ionophore similar to A23187 that can raise intracellular calcium, potentially modulating KChIP4. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
An alkaloid that binds to ryanodine receptors and could modulate intracellular calcium, thereby affecting KChIP4. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
An antagonist of adenosine receptors that can also release stored calcium from the ER, potentially affecting KChIP4. | ||||||