KCC4 Activators
KCC4, a pivotal player in cellular ion homeostasis, operates amidst an intricate web of signaling pathways and regulatory checkpoints. A clutch of compounds, each with unique attributes, has emerged as influencers of KCC4's activity. Compounds like N-Ethylmaleimide and Calyculin A, for instance, set the stage by targeting protein phosphatases. By curbing the dephosphorylation processes that keep KCC4 in check, these chemicals pivot towards the activation of the cotransporter. Staurosporine and Genistein further extend this regulatory tapestry. These kinase inhibitors, while broad in their specificity, can intercept upstream pathways, setting off a cascade that indirectly nudges KCC4.
On another front, ion balance and intracellular signaling messengers form the crux of KCC4's modulatory inputs. Here, chemicals like Forskolin and 8-Br-cAMP, with their ability to elevate cAMP levels, steer the course for ion transporters including KCC4. Similarly, Ionomycin, by augmenting intracellular calcium, has the potential to reshape the signaling pathways intertwined with KCC4.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
Known to activate KCC cotransporters by inhibiting protein phosphatases which maintain the transporter in a deactivated state. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A broad-spectrum kinase inhibitor that can indirectly activate KCC4 by modulating upstream kinase pathways. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $109.00 $228.00 | 9 | |
Although primarily a NKCC inhibitor, its presence may indirectly modify KCC4 activity through ion balance modulation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
A potent inhibitor of protein phosphatases, potentially activating KCC4 by preventing dephosphorylation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylyl cyclase leading to increased cAMP levels which can modulate ion transporters including KCC4. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
A calcium ionophore that can increase intracellular calcium, potentially modulating pathways affecting KCC4. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
A cell-permeable cAMP analog that can modulate ion channels and transporters like KCC4. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits protein phosphatases, potentially leading to KCC4 activation by blocking deactivation pathways. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
Activates AMPK, a kinase known to affect cellular ion balance, possibly influencing KCC4. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A broad-spectrum tyrosine kinase inhibitor that can indirectly modulate KCC4 activity by affecting upstream pathways. | ||||||