Kal1 Activators
Kal1 Activators encompass a diverse set of chemical compounds that indirectly stimulate the functional activity of Kal1 through specific signaling pathways connected to neuronal development and migration. Phorbol 12-myristate 13-acetate (PMA) and Bisindolylmaleimide I, through their modulation of Protein Kinase C (PKC), alter the cytoskeletal dynamics, a cellular function that Kal1 influences in its role in neurite outgrowth. Similarly, cAMP elevators like Forskolin and analogs such as 8-Br-cAMP and db-cAMP, activate PKA, which phosphorylates various targets to regulate neuronal migration and axon guidance, processes that Kal1 is critical for. Sphingosine-1-phosphate acts on G protein-coupled receptors, initiating signaling cascades that affect cytoskeletal organization and cell adhesion, while Retinoic Acid and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) modulate gene expression and cAMP levels,respectively, influencing neuronal differentiation and migration where Kal1 plays a pivotal role. Insulin and Epidermal Growth Factor (EGF) engage the PI3K/Akt and Ras/MAPK pathways to support cell survival, growth, and migration, complementing Kal1's regulatory functions in these areas.
In addition to these mechanisms, the activity of Kal1 is indirectly enhanced by compounds that modify cellular stress and protein synthesis pathways. Anisomycin activates stress-activated protein kinases and p38 MAPK, leading to changes in the cytoskeletal organization that align with Kal1's involvement in neuronal structure and function. Herbimycin A, by inhibiting tyrosine kinase activity, can potentially facilitate signaling toward pathways that govern cell adhesion and neurite outgrowth, enhancing Kal1's role in these processes. Collectively, these Kal1 Activators, through their targeted effects on intracellular signaling, promote the enhancement of Kal1-mediated functions relevant to neurodevelopmental processes without directly increasing its expression or activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a direct activator of Protein Kinase C (PKC), which is involved in multiple signaling pathways, including those that regulate cellular adhesion and migration. The activation of PKC is known to affect cytoskeletal organization, an aspect of cellular function that Kal1 influences through its role in neurite outgrowth and neuronal migration. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP by activating adenylate cyclase, leading to the activation of PKA. PKA phosphorylates various targets that can influence neuronal migration and axon guidance, processes in which Kal1 is implicated. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule activates G protein-coupled receptors, leading to downstream effects on cytoskeletal dynamics and cell adhesion. These processes are relevant to Kal1's function in neuronal development. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
As a cAMP analog, 8-Br-cAMP increases PKA activity, which can enhance neurite outgrowth and guidance, processes that are part of Kal1's functional repertoire. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which is crucial for cell survival, growth, and migration. These cellular processes are known to be modulated by Kal1, especially in the context of neuronal development. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
As a PKC inhibitor, Bisindolylmaleimide I can shift PKC-mediated signaling, indirectly affecting pathways that Kal1 may influence, such as those related to cytoskeletal dynamics and neuronal migration. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA, thereby influencing pathways that regulate neuronal development and migration, functions associated with Kal1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to nuclear receptors and influences gene expression, affecting neuronal differentiation and development. Such processes are fundamental to Kal1's role in brain development. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs) and p38 MAPK, which can lead to reorganization of the cytoskeleton, a cellular aspect influenced by Kal1. | ||||||
Herbimycin A | 70563-58-5 | sc-3516 sc-3516A | 100 µg 1 mg | $272.00 $1502.00 | 13 | |
Herbimycin A is a tyrosine kinase inhibitor that by inhibiting competitive pathways can redirect signaling towards pathways that relate to cellular adhesion, migration, and neurite outgrowth, all of which are processes where Kal1 has a functional role. | ||||||