JWA Activators
JWA Activators is a class of chemical compounds that indirectly enhance the functional activity of the JWA protein through specific cellular pathways. These activators are diverse in their chemical structures and biological actions, yet they share a commonality in their ability to influence JWA's function. This class includes polyphenolic compounds like resveratrol and ellagic acid, bioactive compounds such as curcumin, flavonoids like quercetin, isothiocyanates such as sulforaphane, catechins like EGCG, organic compounds like indole-3-carbinol, and isoflavones such as genistein. Each of these compounds influences JWA's function through its action on specific cellular pathways, including Nrf2, NF-κB, STAT3, AMPK, AhR, and PI3K/Akt.
Resveratrol and ellagic acid, for instance, activate the Nrf2 pathway, which is pivotal in managing oxidative stress, thereby indirectly upregulating JWA. Curcumin and luteolin inhibit NF-κB, a key mediator of inflammation, leading to an indirect enhancement of JWA function. Quercetin and apigenin inhibit the STAT3 pathway, involved in cell growth and apoptosis, resulting in an indirect upregulation of JWA. EGCG and berberine activate the AMPK pathway, crucial in cellular energy homeostasis, thus indirectly enhancing JWA's role. Genistein influences JWA activity by inhibiting the PI3K/Akt pathway, critical for cell survival and growth. Indole-3-carbinol activates the AhR pathway, increasing JWA's function indirectly. With a diverse range of structures and biological activities, these JWA Activators enhance the protein's function through their specific actions on various cellular pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound, can enhance the functional activity of JWA through its influence on the Nrf2 pathway. This pathway is key in cellular responses to oxidative stress and inflammatory processes. By activating Nrf2, resveratrol indirectly upregulates JWA, which is known for its role in antioxidant stress responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a bioactive compound that can enhance JWA activity via the NF-κB pathway. Curcumin's known for its anti-inflammatory properties, largely mediated through the inhibition of NF-κB. JWA is involved in the same pathway, thus curcumin indirectly upregulates JWA, amplifying its activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that can stimulate JWA activity via the STAT3 pathway. Quercetin inhibits STAT3, which indirectly enhances the activation of JWA, given its role in the regulation of this pathway. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, an isothiocyanate, can impact JWA via the Nrf2 pathway. It's known to stimulate Nrf2, and since JWA is involved in this pathway, sulforaphane indirectly upregulates JWA. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a catechin, can stimulate JWA activity via the AMPK pathway. EGCG activates AMPK, leading to an indirect upregulation of JWA, given its role in AMPK signaling. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol can enhance JWA activity through the AhR pathway. By activating AhR, Indole-3-carbinol indirectly upregulates JWA, which regulates the AhR pathway. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $71.00 $296.00 $612.00 | 19 | |
CAPE can enhance JWA activity via the NF-κB pathway. It is known to inhibit NF-κB, and as JWA is involved in this pathway, CAPE indirectly stimulates JWA. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, enhances JWA activity through the PI3K/Akt pathway. Genistein inhibits PI3K/Akt, leading to an indirect enhancement of JWA, given its role in the PI3K/Akt pathway. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin, a flavone, can influence JWA activity through the STAT3 pathway. By inhibiting STAT3, apigenin indirectly upregulates JWA, given its role in this pathway. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin can stimulate JWA activity via the NF-κB pathway. Luteolin inhibits NF-κB, leading to an indirect enhancement of JWA's role in this pathway. | ||||||