Jade-1 Inhibitors
Chemical inhibitors of Jade-1 can affect its function through various mechanisms related to the modification of the cellular protein degradation pathways. Proteasome inhibitors like MG132, Epoxomicin, Lactacystin, and Bortezomib (PS-341) can disrupt the ubiquitin-proteasome system, leading to an accumulation of ubiquitinated proteins. Jade-1, which is linked with histone deubiquitination and proteasomal degradation, may find its function inhibited as these inhibitors prevent the normal degradation of proteins that Jade-1 targets, creating a cellular environment that is not conducive to Jade-1's normal operation.
Additionally, inhibitors that target other proteases, such as ALLN (Calpain Inhibitor I), which also affects the proteasome, E-64, a cysteine protease inhibitor, Leupeptin, which inhibits serine and cysteine proteases, Pepstatin A, an aspartyl protease inhibitor, Aprotinin, affecting several serine proteases, and Chymostatin, acting on chymotrypsin-like proteases, can modify the proteolytic balance within the cell. Although Jade-1 is not directly involved in the activities targeted by these inhibitors, the resulting alteration in the proteolytic environment can indirectly inhibit the functional role of Jade-1. This is because the stability and turnover of the proteins that Jade-1 interacts with can be affected, which in turn can disrupt the protein degradation machinery that Jade-1 is a part of. PI-1840, as a threonine protease inhibitor, follows a similar rationale; by hindering proteasome function, it can cause an accumulation of proteins that Jade-1 would typically be involved with in the degradation process, thereby indirectly inhibiting Jade-1's role in the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor. Since Jade-1 is involved in ubiquitin-mediated proteasomal degradation, inhibiting the proteasome can result in the accumulation of proteins that are normally degraded. This can lead to a cellular environment that impedes Jade-1's function in targeting specific proteins for degradation. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
Epoxomicin is another proteasome inhibitor. By impeding the proteasomal degradation pathway, Epoxomicin can lead to an accumulation of ubiquitinated proteins which may disrupt the functional role of Jade-1 in targeting proteins for degradation through the ubiquitin-proteasome system. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E-64 is a cysteine protease inhibitor. While Jade-1 is not a cysteine protease, the inhibition of these proteases can alter the protein degradation pathways in the cell, which can indirectly affect the functional role of Jade-1, given its involvement in protein degradation processes. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Lactacystin is a specific inhibitor of the proteasome. It can inhibit the degradation of ubiquitinated proteins, which is a process that Jade-1 is involved in. This proteasome inhibition can therefore interfere with Jade-1's role in regulating protein turnover through the ubiquitin-proteasome pathway. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a well-known proteasome inhibitor used to block the breakdown of polyubiquitinated proteins, which can disrupt the Jade-1-associated pathways that mediate proteasomal degradation, indirectly inhibiting the function of Jade-1. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Leupeptin is an inhibitor of serine and cysteine proteases. By inhibiting these proteases, leupeptin can affect the protein degradation pathway, which could indirectly interfere with Jade-1's role within the cell, as Jade-1 has been implicated in histone deubiquitination linked to protein degradation. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $110.00 $400.00 $1615.00 | 51 | |
Aprotinin is a protease inhibitor that acts on several serine proteases. By inhibiting these proteases, aprotinin can modify the proteolytic environment in the cell, which could in turn disturb Jade-1's protein regulatory functions, as Jade-1 is part of the protein degradation machinery in the cell. | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | $153.00 $255.00 $627.00 $1163.00 $2225.00 | 3 | |
Chymostatin is a protease inhibitor that affects chymotrypsin-like proteases. By inhibiting these enzymes, chymostatin may alter the balance of protein turnover in the cell, potentially hindering the role of Jade-1 in protein degradation. | ||||||