Jade-1 Activators
Jade-1 Activators are a class of chemical compounds that can enhance the functional activity of Jade-1, a protein known for its role in enhancing the ubiquitination and degradation of the oncogene β-catenin. Jade-1 is a short-lived protein that is stabilized by the kidney tumor suppressor protein von Hippel-Lindau (VHL). It has histone acetyltransferase (HAT) activity and is associated with chromatin, indicating a role in gene transcription regulation. Jade-1 activators work by either altering the protein degradation pathway, impacting chromatin structure, or affecting the methylation status of DNA.
Some Jade-1 activators, such as Rapamycin, work by influencing the protein degradation pathway. Rapamycin, an mTOR inhibitor, stimulates Jade-1 activity by inhibiting the mTOR pathway, which is known to regulate Jade-1 stabilization. Other Jade-1 activators, including Trichostatin A, Vorinostat (Suberoylanilide Hydroxamic Acid), Sodium Butyrate, Sirtinol, and Nicotinamide, function by impacting chromatin structure. These compounds are histone deacetylase inhibitors that can alter chromatin structure and gene expression, leading to enhanced Jade-1 functional activity, given its role as a histone binding protein. Furthermore, Jade-1 activators such as 5-Azacytidine, Decitabine, and Zebularine function by influencing the methylation status of DNA. These DNA methyltransferase inhibitors can cause DNA hypomethylation, which can lead to increased expression of Jade-1, thereby enhancing its functional activation. In addition, Parthenolide, a NF-kB inhibitor, can disrupt the degradation of Jade-1, leading to its functional activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that can stimulate the activity of Jade-1 by inhibiting the mTOR pathway, which is known to regulate Jade-1 stabilization. By inhibiting mTOR, Rapamycin can lead to the enhancement of Jade-1 activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By inhibiting histone deacetylase, it may impact chromatin structure, which can enhance the functional activity of Jade-1, a known histone binding protein. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is a histone deacetylase inhibitor that can impact chromatin structure. Given that Jade-1 is a known histone binding protein, Vorinostat could enhance Jade-1's functional activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate is a histone deacetylase inhibitor that can alter chromatin structure. Since Jade-1 is known to bind to histones, sodium butyrate could enhance Jade-1's functional activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can cause hypomethylation of DNA. Hypomethylation could lead to the increased expression of Jade-1, which is a known histone binding protein, enhancing its functional activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine is a DNA methyltransferase inhibitor that can lead to hypomethylation of DNA, potentially leading to the increased expression of Jade-1, a known histone binding protein, enhancing its functional activity. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $37.00 $111.00 | 14 | |
Sirtinol is a sirtuin inhibitor that can impact chromatin structure and gene expression. Given that Jade-1 is a known histone binding protein, Sirtinol could enhance Jade-1's functional activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide is a sirtuin inhibitor that can impact chromatin structure and gene expression. Since Jade-1 is known to bind to histones, Nicotinamide could enhance Jade-1's functional activity. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
Zebularine is a DNA demethylase inhibitor, which can cause DNA hypomethylation. Hypomethylation can lead to increased expression of Jade-1, a known histone binding protein, thereby enhancing its functional activity. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide is a NF-kB inhibitor. By inhibiting NF-kB, it could disrupt the degradation of Jade-1, a protein known to be negatively regulated by NF-kB, thereby leading to its functional activation. | ||||||