IVD Inhibitors
IVD inhibitors belong to a specialized class of chemical compounds designed to target the IVD (Isovaleryl-CoA Dehydrogenase) enzyme. IVD is a critical component of the metabolic pathway known as branched-chain amino acid (BCAA) degradation. This pathway is responsible for breaking down BCAAs, which include valine, leucine, and isoleucine, into intermediates that can be further processed to generate energy or used for various cellular functions. IVD specifically catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA, a crucial step in the catabolism of valine.
Inhibitors of IVD are designed to interact with this enzyme and disrupt its catalytic activity. These inhibitors may operate through various mechanisms, such as binding to specific active sites on IVD or altering its conformation. By inhibiting IVD, these compounds can interfere with the breakdown of BCAAs and disrupt the normal metabolic flux within the BCAA degradation pathway. Research on IVD inhibitors is primarily focused on unraveling the molecular mechanisms by which IVD participates in valine catabolism and its role in maintaining cellular energy homeostasis. Understanding how IVD inhibitors affect this pathway contributes to our knowledge of amino acid metabolism and the regulation of energy production in cells.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An HDAC inhibitor that could epigenetically modify the expression of genes, potentially including IVD, by altering chromatin structure. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that may affect DNA methylation and gene expression profiles, including that of IVD. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
HDAC inhibitor that might indirectly suppress IVD expression by changing the epigenetic landscape of the gene. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Another HDAC inhibitor that could lead to hyperacetylation of histones and possible downregulation of IVD expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
A well-known HDAC inhibitor that may alter gene expression patterns, potentially including those related to IVD. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
A compound that binds to G-C rich sequences in DNA, potentially affecting the transcription of certain genes such as IVD. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Known to modulate various signaling pathways and could non-specifically affect the transcription of genes like IVD. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Affects gene expression by activating nuclear receptors and may alter the expression of IVD indirectly. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Acts on bacterial RNA polymerase; in eukaryotes, it could potentially influence gene expression including IVD. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Interacts with DNA and inhibits RNA polymerase, which could decrease the transcription of many genes, including IVD. | ||||||