IRSp53 Activators
The IRSp53 Activators chemical class encompasses a variety of compounds that indirectly influence the activity of IRSp53, a protein integral to cytoskeletal organization and membrane protrusion formation. These compounds primarily function by modulating signaling pathways and cellular processes that are related to IRSp53's role in the cell. Compounds such as Phosphatidylinositol 4,5-Bisphosphate (PIP2), Epidermal Growth Factor (EGF), and activators of Rac1 represent key members of this class, highlighting the connection between IRSp53 and cytoskeletal dynamics. PIP2 directly interacts with IRSp53, affecting its role in actin cytoskeletal dynamics and membrane deformation. EGF, through its activation of signaling pathways, influences IRSp53's involvement in cytoskeletal rearrangement and cell motility. Rac1 activators further underscore the importance of small GTPase signaling in regulating IRSp53's function in actin polymerization and membrane ruffling.
Other notable compounds in this class, including Phorbol 12-Myristate 13-Acetate (PMA), Forskolin, Lithium Chloride, and Caffeine, contribute to the modulation of IRSp53 activity through various signaling mechanisms. PMA activates protein kinase C (PKC), which is involved in pathways affecting IRSp53's role in cytoskeletal organization. Forskolin, by elevating cAMP levels, and Lithium Chloride, through its influence on GSK-3β signaling, demonstrate the diverse molecular pathways that can impact IRSp53 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can indirectly influence IRSp53 through signaling pathways related to cytoskeletal organization. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises cAMP levels, potentially affecting signaling pathways that modulate IRSp53's function in cytoskeletal dynamics. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can modulate GSK-3β signaling, potentially affecting pathways linked to IRSp53 and its role in cytoskeletal reorganization. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine influences various signaling pathways and might indirectly affect IRSp53's role in actin dynamics. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates multiple signaling pathways, potentially impacting IRSp53's activity in cell morphology and motility. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol affects various signaling molecules, potentially influencing IRSp53's function in cytoskeletal organization. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can modulate signaling pathways involved in cell motility and cytoskeletal dynamics, potentially influencing IRSp53. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P can influence cellular signaling pathways, potentially affecting IRSp53's role in actin cytoskeletal dynamics. | ||||||