IRP-1 Activators
The class of IRP-1 activators comprises a diverse array of chemicals that modulate cellular processes involved in iron metabolism. These compounds offer unique avenues for exploring the activation or modulation of IRP-1 and its regulatory functions. Nitric oxide, a signaling molecule, indirectly activates IRP-1 by influencing cellular redox status, providing insights into the redox-sensitive regulatory mechanisms of IRP-1. L-ascorbic acid (Vitamin C) enhances non-heme iron absorption, indirectly influencing IRP-1 activity and its regulation of iron-responsive elements (IREs).
Metabolites such as alpha-ketoglutarate, succinic acid, and cis-aconitic acid, from cellular energy metabolism, indirectly activate IRP-1 by impacting cellular energy status. These chemicals highlight the intricate connection between cellular energy metabolism and iron homeostasis, suggesting avenues for exploration. Electrophiles like diethyl maleate and dimethyl fumarate induce oxidative stress, providing a unique approach to indirectly activate IRP-1 through modulation of cellular redox conditions. Compounds such as succinylacetone and sodium nitroprusside act through diverse mechanisms, influencing heme biosynthesis and releasing nitric oxide, respectively, to impact IRP-1 activity. These chemicals open avenues for understanding the complex regulatory networks governing IRP-1 function. The class of IRP-1 activators offers valuable tools for investigating the dynamic interplay between cellular processes, energy metabolism, and iron homeostasis, contributing to a deeper understanding of IRP-1-mediated pathways in health and disease.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
L-ascorbic acid, commonly known as Vitamin C, acts as an indirect activator of IRP-1 by influencing iron availability. Vitamin C enhances non-heme iron absorption, potentially impacting the activity of IRP-1 and its regulation of iron-responsive elements (IREs). This chemical modulation of iron homeostasis through Vitamin C administration provides a potential avenue for indirectly influencing IRP-1-mediated processes involved in iron metabolism. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
Alpha-ketoglutarate, an intermediate in the Krebs cycle, acts as an indirect activator of IRP-1 by influencing cellular energy metabolism. The Krebs cycle-derived metabolite may impact the activity of IRP-1, as cellular energy status is known to influence iron homeostasis. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $45.00 $75.00 $133.00 | ||
Succinic acid, a key intermediate in cellular metabolism, acts as an indirect activator of IRP-1 by influencing cellular energy status. The metabolite may impact the activity of IRP-1, as cellular energy levels are known to influence iron homeostasis. | ||||||
cis-Aconitic acid | 585-84-2 | sc-257251 sc-257251A | 1 g 5 g | $99.00 $405.00 | ||
Cis-aconitic acid, an isomer of aconitic acid in the Krebs cycle, acts as an indirect activator of IRP-1 by influencing cellular energy metabolism. The metabolite may impact the activity of IRP-1, as cellular energy status is known to influence iron homeostasis. | ||||||
Diethylmaleate | 141-05-9 | sc-202577 | 5 g | $27.00 | 4 | |
Diethylmaleate acts as an indirect activator of IRP-1 by influencing cellular redox status. As an electrophile, diethyl maleate can induce oxidative stress, potentially impacting the redox-sensitive regulatory function of IRP-1. The exact mechanism through which diethyl maleate affects IRP-1 requires further investigation, but this chemical provides a unique avenue for exploring the modulation of IRP-1-mediated processes through alterations in cellular redox conditions. | ||||||
Succinylacetone | 51568-18-4 | sc-212963 sc-212963B | 10 mg 100 mg | $336.00 $418.00 | ||
Succinylacetone, an inhibitor of delta-aminolevulinic acid dehydratase (ALAD), indirectly activates IRP-1 by influencing heme biosynthesis. By inhibiting ALAD, succinylacetone disrupts heme synthesis, potentially impacting the activity of IRP-1 and its regulation of iron-responsive elements (IREs). | ||||||
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $28.00 | 6 | |
Dimethyl fumarate acts as an indirect activator of IRP-1 by influencing cellular redox status. As an electrophile, dimethyl fumarate induces oxidative stress, potentially impacting the redox-sensitive regulatory function of IRP-1. The exact mechanism through which dimethyl fumarate affects IRP-1 requires further investigation, but this chemical provides a unique avenue for exploring the modulation of IRP-1-mediated processes through alterations in cellular redox conditions. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid acts as an indirect activator of IRP-1 by influencing cellular redox status. As a potent antioxidant, alpha-lipoic acid modulates oxidative stress, potentially impacting the redox-sensitive regulatory function of IRP-1. The exact mechanism through which alpha-lipoic acid affects IRP-1 requires further investigation, but this chemical provides a unique avenue for exploring the modulation of IRP-1-mediated processes through alterations in cellular redox conditions. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
L-methionine, an essential amino acid, acts as an indirect activator of IRP-1 by influencing cellular redox status. As a precursor to glutathione, L-methionine can modulate oxidative stress, impacting the redox-sensitive regulatory function of IRP-1. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Sodium nitroferricyanide(III) dihydrate acts as an indirect activator of IRP-1 by releasing nitric oxide (NO), influencing cellular redox status. NO modulates oxidative stress, impacting the redox-sensitive regulatory function of IRP-1. The exact mechanism through which sodium nitroprusside affects IRP-1 requires further investigation, but this chemical provides a unique avenue for exploring the modulation of IRP-1-mediated processes through alterations in cellular redox conditions. | ||||||