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Succinylacetone (CAS 51568-18-4)

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Alternate Names:
Succinylacetone is also known as 4,6-Dioxoheptanoic Acid.
Application:
Succinylacetone is a catabolic byproduct of tyrosine breakdown and an inhbitor of heme biosynthesis.
CAS Number:
51568-18-4
Molecular Weight:
158.15
Molecular Formula:
C7H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Succinylacetone is an organic compound widely employed in scientific research as an inhibitor of the enzyme 5-aminolevulinic acid dehydratase (ALAD), which is pivotal in the biosynthesis of heme, the iron-containing compound found in hemoglobin. Researchers use Succinylacetone to study the metabolic pathways involved in heme production and to understand the biochemical basis of certain metabolic disorders. It is also used as a standard in analytical techniques like chromatography for the quantification of its concentration in biological samples. In biochemistry, it serves as a tool to probe the effects of disrupted heme synthesis on cellular processes. Furthermore, Succinylacetone′s role in research extends to agricultural science, where it is involved in studies on plant growth and development, particularly in relation to chlorophyll production and the synthesis of other heme-containing enzymes essential for plant metabolism.


Succinylacetone (CAS 51568-18-4) References

  1. Spectrophotometric microassay for delta-aminolevulinate dehydratase in dried-blood spots as confirmation for hereditary tyrosinemia type I.  |  Schulze, A., et al. 2001. Clin Chem. 47: 1424-9. PMID: 11468232
  2. Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase.  |  Lindstedt, S., et al. 1992. Lancet. 340: 813-7. PMID: 1383656
  3. Newborn screening for hepatorenal tyrosinemia by tandem mass spectrometry: analysis of succinylacetone extracted from dried blood spots.  |  Allard, P., et al. 2004. Clin Biochem. 37: 1010-5. PMID: 15498530
  4. Tyrosinaemia type I--an update.  |  Kvittingen, EA. 1991. J Inherit Metab Dis. 14: 554-62. PMID: 1749221
  5. [Application of succinylacetone levels measurement in the blood and urine in the diagnosis of tyrosinemia type 1].  |  Han, LS., et al. 2012. Zhonghua Er Ke Za Zhi. 50: 126-30. PMID: 22455637
  6. Plasma succinylacetone is persistently raised after liver transplantation in tyrosinaemia type 1.  |  Bartlett, DC., et al. 2013. J Inherit Metab Dis. 36: 15-20. PMID: 22456946
  7. Urinary Succinylacetone Analysis by Gas Chromatography-Mass Spectrometry (GC-MS).  |  Chen, H. and Yu, C. 2016. Methods Mol Biol. 1378: 281-90. PMID: 26602140
  8. A GC/MS method for determination of succinylacetone in Arabidopsis thaliana.  |  Zhou, L., et al. 2016. Anal Bioanal Chem. 408: 4661-7. PMID: 27086013
  9. Simultaneous quantification of succinylacetone and nitisinone for therapeutic drug monitoring in the treatment of Tyrosinemia type 1.  |  Sundberg, J., et al. 2018. J Chromatogr B Analyt Technol Biomed Life Sci. 1072: 259-266. PMID: 29195145
  10. Inter-laboratory analytical improvement of succinylacetone and nitisinone quantification from dried blood spot samples.  |  Laeremans, H., et al. 2020. JIMD Rep. 53: 90-102. PMID: 32395414
  11. The Importance of Succinylacetone: Tyrosinemia Type I Presenting with Hyperinsulinism and Multiorgan Failure Following Normal Newborn Screening.  |  Priestley, JRC., et al. 2020. Int J Neonatal Screen. 6: PMID: 32832707
  12. Hereditary tyrosinemia type Ⅰ: newborn screening, diagnosis and treatment.  |  Tang, Y. and Kong, Y. 2021. Zhejiang Da Xue Xue Bao Yi Xue Ban. 50: 514-523. PMID: 34704422
  13. Development of Flow Injection Analysis Method for the Second-Tier Estimation of Succinylacetone in Dried Blood Spot of Newborn Screening.  |  Varughese, B., et al. 2022. Indian J Clin Biochem. 37: 40-50. PMID: 35125692

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Succinylacetone, 10 mg

sc-212963
10 mg
$336.00

Succinylacetone, 100 mg

sc-212963B
100 mg
$418.00

What is the stability if Succinylacetone after resuspension in water? How should it be stored?

Asked by: Allie
Thank you for your question . Unfortunately we do not test for this so we don’t have this information.
Answered by: BlakeJ
Date published: 2023-05-05
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Rated 5 out of 5 by from Fuse Y; et alFuse Y; et al. (PubMed ID: 25982796) determined that Succinylacetone reduced the Nrf2a-mediated hmox1ainduction in zebrafish. -SCBT Publication Review
Date published: 2015-06-27
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Succinylacetone is rated 5.0 out of 5 by 1.
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