IRAK-1 Activators
IRAK-1 activators are a class of chemical compounds that specifically engage and modulate the activity of Interleukin-1 Receptor-Associated Kinase 1 (IRAK-1), a critical enzyme in the intracellular signaling pathways. IRAK-1 is an essential kinase that plays a pivotal role in the signal transduction initiated by the interleukin-1 receptor (IL-1R) as well as the Toll-like receptors (TLRs), which are instrumental in the innate immune response. The activation of IRAK-1 is a key step in propagating the signaling cascade that leads to the activation of transcription factors and the expression of certain genes. IRAK-1 activators are therefore involved in modulating the innate immune response by affecting the kinase activity of IRAK-1. These molecules can be varied in structure, ranging from small organic compounds to larger biomolecules, and are characterized by their ability to bind to and increase the enzymatic activity of IRAK-1.
The specificity and mode of action of IRAK-1 activators can greatly differ between different chemical entities. Some IRAK-1 activators might bind directly to the kinase domain of the enzyme, leading to a conformational change that results in its activation. Others might interact with regulatory domains of the protein or with associated adapter molecules, resulting in enhanced recruitment and auto-phosphorylation of IRAK-1, a prerequisite for its full activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $133.00 | 12 | |
Selective inhibitor of IRAK-1 and IRAK-4, suppressing the activation of the IRAK-1 signaling pathway and subsequently leading to reduced pro-inflammatory responses. | ||||||
Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor Inhibitor | 509093-47-4 | sc-204013 | 5 mg | $163.00 | 2 | |
Dual inhibitor targeting both IRAK-1 and IRAK-4, disrupting the IRAK-1-mediated signaling cascade and modulating the immune response. | ||||||
SC514 | 354812-17-2 | sc-205504 sc-205504A | 5 mg 10 mg | $67.00 $91.00 | 13 | |
Selective inhibitor of IKK-2 (a downstream target of IRAK-1), indirectly affecting IRAK-1 signaling by suppressing NF-κB activation, leading to a downregulation of inflammatory responses. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Natural stilbene compound that inhibits IRAK-1 activity, blocking its phosphorylation and subsequent downstream signaling, thereby mitigating inflammatory responses. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibitor of NF-κB activation, indirectly affecting IRAK-1 signaling by preventing the translocation of NF-κB to the nucleus and modulating the inflammatory response. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Diterpene triepoxide that suppresses IRAK-1 expression and activity, inhibiting its signaling cascade and subsequently reducing inflammatory cytokine production. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Natural polyphenol that inhibits IRAK-1 activity and downstream signaling, modulating the inflammatory response by interfering with IRAK-1-mediated NF-κB activation. | ||||||
BX 795 | 702675-74-9 | sc-281689 sc-281689A sc-281689C sc-281689B sc-281689D sc-281689E | 2 mg 5 mg 10 mg 25 mg 50 mg 100 mg | $219.00 $273.00 $331.00 $495.00 $882.00 $1489.00 | 5 | |
Inhibitor of TBK1 and IKK-ε, downstream targets of IRAK-1, affecting the IRAK-1 signaling pathway and modulating inflammatory responses. | ||||||
Resatorvid | 243984-11-4 | sc-476758 | 5 mg | $367.00 | ||
Selective Toll-like receptor 4 (TLR4) signaling inhibitor, indirectly impacting IRAK-1 signaling by blocking TLR4-mediated activation, leading to the suppression of pro-inflammatory responses. | ||||||