Molecular structure of Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor, CAS Number: 509093-47-4
Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor Inhibitor (CAS 509093-47-4)
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Alternate Names:
1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole; N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole
Application:
Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor is a potent and selective inhibitor of IL-1 kinases
CAS Number:
509093-47-4
Purity:
≥95%
Molecular Weight:
395.42
Molecular Formula:
C20H21N5O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor is a specialized small molecule designed to target and selectively inhibit the interleukin-1 receptor-associated kinase 1 and 4 (IRAK1/4). It belongs to a class of compounds known as kinase inhibitors, which specifically block the activity of protein kinases. In vitro studies have revealed that the Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor effectively suppresses IRAK-1/4 activity and reduces the expression of pro-inflammatory cytokines. The mechanism of action underlying the Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor involves inhibiting the IRAK-1/4 enzyme itself. The IRAK-1/4 enzyme plays a critical role in activating the NF-κB signaling pathway.
Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor Inhibitor (CAS 509093-47-4) References
- Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells. | Bhattacharyya, S., et al. 2007. Am J Physiol Gastrointest Liver Physiol. 293: G429-37. PMID: 17540779
- ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8. | Bhattacharyya, S., et al. 2009. Inflamm Bowel Dis. 15: 673-83. PMID: 19085995
- Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling. | Wang, J., et al. 2011. J Biol Chem. 286: 10225-32. PMID: 21245149
- Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. | Yang, YF., et al. 2011. Neuroscience. 196: 25-34. PMID: 21925238
- Interleukin-1 Receptor-Associated Kinase 1/4 as a Novel Target for Inhibiting Neointimal Formation After Carotid Balloon Injury. | Bai, S., et al. 2015. J Atheroscler Thromb. 22: 1317-37. PMID: 26310493
- Targeting Myddosome Signaling in Waldenström's Macroglobulinemia with the Interleukin-1 Receptor-Associated Kinase 1/4 Inhibitor R191. | Ni, H., et al. 2018. Clin Cancer Res. 24: 6408-6420. PMID: 30126942
- Inhibition of Interleukin-1 Receptor-Associated Kinases 1/4, Increases Gene Expression and Serum Level of Adiponectin in Mouse Model of Insulin Resistance. | Rajaie, A., et al. 2018. Int J Mol Cell Med. 7: 185-192. PMID: 31565650
- Safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06650833, a selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, in single and multiple ascending dose randomized phase 1 studies in healthy subjects. | Danto, SI., et al. 2019. Arthritis Res Ther. 21: 269. PMID: 31805989
- A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. | Scarneo, SA., et al. 2020. J Biol Chem. 295: 1565-1574. PMID: 31914413
- Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors. | Tanaka, Y., et al. 2022. Nat Commun. 13: 271. PMID: 35022428
- Interleukin-1 receptor associated kinase 1/4 and bromodomain and extra-terminal inhibitions converge on NF-κB blockade and display synergistic antitumoral activity in activated B-cell subset of diffuse large B-cell lymphoma with MYD88 L265P mutation. | Dlouhy, I., et al. 2022. Haematologica. 107: 2990. PMID: 36453521
Inhibitor of:
ARHGAP (Rho GTPase activating protein), DENND2D, DOCK 7, IRAK-1, IRAK-4, IRAK-M, rhophilin, and TL.Activator of:
ARHGAP24, FGD1, and IRAK-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor, 5 mg | sc-204013 | 5 mg | $163.00 |