INTS12 Inhibitors
INTS12 inhibitors belong to a specialized class of chemical compounds designed to selectively impede the activity of the INTS12 protein, a component of the Integrator complex involved in the processing of small nuclear RNAs (snRNAs). The Integrator complex has a significant role in gene expression regulation, particularly in the snRNA processing which is pivotal for the functioning of the spliceosome, an essential cellular machinery responsible for mRNA splicing. INTS12 inhibitors act by targeting the protein-protein interactions or the active sites within INTS12, thereby disrupting its function within the Integrator complex. The inhibition of INTS12 can lead to the accumulation of unprocessed snRNAs, consequently affecting the maturation of spliceosomal snRNPs (small nuclear ribonucleoproteins) and ultimately impacting the splicing fidelity of pre-mRNA. This class of inhibitors is characterized by their specificity in binding to the INTS12 protein, thereby ensuring minimal off-target effects on other components of the splicing machinery. The selectivity is achieved through molecular structures that are complementary to INTS12's unique binding sites or allosteric sites, which are distinct from those of other Integrator complex proteins.
The inhibition mechanisms of INTS12 inhibitors are complex and multifaceted. They can act by directly binding to the INTS12 active site, thus preventing the association of INTS12 with other Integrator complex components, or by inducing conformational changes in the protein that negate its functionality. Some inhibitors may interfere with the recruitment of the Integrator complex to the snRNA genes, thereby blocking the snRNA processing at an early stage. Others might obstruct the catalytic activity of INTS12, which is necessary for the cleavage of snRNA transcripts. By targeting INTS12, these compounds effectively derail the proper assembly or activity of the Integrator complex, emphasizing the importance of INTS12 in snRNA processing and gene expression regulation. The design of INTS12 inhibitors is grounded in a detailed understanding of the protein's structure, the dynamics of the Integrator complex, and the precise molecular interactions that are essential for INTS12's operational role. This specificity makes INTS12 inhibitors a potent tool for dissecting the biological functions of INTS12 and for studying the intricate processes of snRNA processing and mRNA splicing regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent non-selective inhibitor of protein kinases. INTS12 function may be indirectly inhibited through kinase signaling pathways that INTS12 is involved in. Kinase inhibition can prevent phosphorylation events necessary for INTS12's role in protein complex assembly. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, this compound can alter the AKT signaling pathway, which is involved in various cellular processes including mRNA processing that INTS12 might be involved in. Reduced AKT activity can lead to decreased INTS12 function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that, by inhibiting MEK, prevents the activation of the MAPK/ERK pathway. If INTS12 is involved in regulating mRNA processing related to this pathway, inhibiting MEK could indirectly lessen INTS12 activity by reducing substrate availability. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. As mTOR is a key regulator of cell growth and proliferation, its inhibition can affect the processing of mRNA. If INTS12 is involved in the mTOR signaling pathway, its activity would be decreased. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is also a MEK inhibitor, similarly to PD98059, and it works by inhibiting the MAPK/ERK pathway. INTS12's activity, if related to mRNA processing within this pathway, would be indirectly diminished due to reduced upstream signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that disrupts cytokine signaling. If INTS12 is involved in cytokine-mediated mRNA processing, inhibition of p38 MAPK could lead to a decrease in INTS12 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor, like LY294002. By inhibiting PI3K, it affects various signaling pathways including AKT. This could lead to a decrease in INTS12 activity if INTS12 is part of the mRNA processing machinery regulated by AKT. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which may affect transcription factors and mRNA processing. If INTS12 functions within a JNK-regulated pathway, the inhibition of JNK would result in a decrease in INTS12 activity. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $47.00 | 2 | |
ZM336372 is a Raf kinase inhibitor, which could indirectly inhibit INTS12 by reducing the activity of the MAPK/ERK pathway, assuming INTS12 is involved in mRNA processing within this signaling cascade. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine is an AKT inhibitor. By inhibiting AKT, it can suppress the PI3K/AKT/mTOR pathway. If INTS12 functions downstream of AKT, its activity would be decreased as a result of AKT inhibition. | ||||||