INTS12 Activators
INTS12 activators are a class of chemical compounds that interact with the Integrator complex subunit 12 (INTS12), which is a part of a larger multi-subunit Integrator complex. This complex plays a crucial role in the biochemistry of eukaryotic cells, particularly in the processing of RNA. The Integrator complex is involved in the 3'-end processing of uridine-rich small nuclear RNAs (UsnRNAs), which are essential components of the spliceosome, the cellular machinery responsible for the splicing of pre-messenger RNA (mRNA). The specificity of INTS12 activators lies in their ability to modulate the activity of the Integrator complex by targeting INTS12, which can lead to alterations in the processing efficiency or pattern of RNA transcripts.
INTS12 activators can be small molecules, peptides, or other forms of chemical modulators that have been identified or designed through various methods, such as high-throughput screening, rational drug design, or combinatorial chemistry. The interaction of these activators with INTS12 can result in changes in the conformation of the Integrator complex, which may affect its interaction with RNA polymerase II (Pol II), the enzyme responsible for synthesizing mRNA from DNA. By modulating the function of INTS12, these activators influence the transcriptional landscape of cells, as the correct processing of UsnRNAs is vital for the accurate removal of introns from pre-mRNA. This, in turn, ensures the proper maturation of mRNA molecules, which are then translated into functional proteins. INTS12 activators thus have a profound impact on the fundamental processes of gene expression and regulation, affecting how genetic information is ultimately expressed within a cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels, thus activating PKA. PKA can phosphorylate various substrates and proteins, potentially leading to indirect enhancement of INTS12 activity by influencing cellular processes that INTS12 is involved in. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4 (PDE4) and consequently raises intracellular cAMP levels, which could lead to PKA activation and indirectly enhance INTS12 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, increasing intracellular calcium levels and potentially activating calcium-dependent signaling pathways that might indirectly enhance the activity of INTS12. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Br-cAMP is a cAMP analog that activates PKA and can mimic the effects of cAMP, potentially leading to the enhancement of INTS12 activity through PKA-dependent signaling pathways. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine, known for modulating autophagy and endosomal acidification, might indirectly influence INTS12 activity through alterations in cellular trafficking and degradation pathways. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that by preventing protein degradation, may lead to an accumulation of proteins that interact with INTS12, indirectly enhancing its activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, which could lead to altered phosphorylation states of proteins within the INTS12 pathway, indirectly enhancing INTS12 activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β, potentially influencing Wnt signaling and other pathways, which may indirectly lead to enhanced INTS12 activity through changes in cellular context. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that can lead to the modulation of the MAPK signaling pathway, potentially impacting the functional activity of INTS12 through indirect signaling cascades. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, which by shifting the signaling balance might lead to the enhancement of INTS12 activity, as p38 MAPK influences various cellular functions. | ||||||