Intersectin-2 Inhibitors
Intersectin-2 inhibitors are a class of chemical compounds designed to target and inhibit the function of the protein Intersectin-2, which is involved in various cellular processes, particularly those related to endocytosis, signal transduction, and cytoskeletal dynamics. Intersectin-2 is a multi-domain scaffolding protein that plays a crucial role in clathrin-mediated endocytosis, a process through which cells internalize extracellular molecules and membrane receptors. By interacting with several other proteins involved in membrane trafficking, actin cytoskeleton remodeling, and signaling pathways, Intersectin-2 coordinates the complex network of molecular events that regulate endocytosis, vesicle formation, and signal propagation. Inhibitors of Intersectin-2 aim to disrupt its ability to mediate these protein-protein interactions, thus altering endocytic processes and downstream cellular signaling events.
The design of Intersectin-2 inhibitors typically focuses on targeting specific domains of the protein that are responsible for its interactions with other molecules. These domains may include SH3 (Src homology 3) domains, which are crucial for binding to proline-rich motifs in other proteins, or EH (Eps15 homology) domains, which are involved in endocytic machinery assembly. By inhibiting these interactions, the compounds interfere with the proper functioning of the endocytic and signaling pathways regulated by Intersectin-2. The inhibitors generally interact with the target protein through non-covalent forces such as hydrogen bonding, van der Waals forces, and hydrophobic interactions, ensuring that they bind specifically to the functional regions of Intersectin-2. By studying the effects of Intersectin-2 inhibition, researchers can gain insights into how this protein contributes to cellular trafficking, signal transduction, and the regulation of the cytoskeleton, as well as its broader role in maintaining cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a dynamin inhibitor that directly impacts Intersectin-2 by disrupting endocytosis. Intersectin-2 interacts with dynamin during endocytic processes, and Dynasore inhibits this interaction, leading to modulation of Intersectin-2 activity and downstream cellular processes. | ||||||
Dynole 34-2 | 1128165-88-7 | sc-362731 sc-362731A | 10 mg 50 mg | $205.00 $849.00 | ||
Amphiphysin inhibitor, also known as Dynole 34-2, directly targets Intersectin-2 by interfering with clathrin-mediated endocytosis. Intersectin-2 interacts with amphiphysin during this process, and Dynole 34-2 disrupts this interaction, modulating Intersectin-2 activity and influencing cellular processes associated with endocytosis. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
N-Ethylmaleimide (NEM) indirectly influences Intersectin-2 by targeting vesicle trafficking. NEM inhibits vesicle fusion processes, which can impact the cellular pathways involving Intersectin-2. The modulation of vesicle trafficking by NEM indirectly influences Intersectin-2 functions and downstream cellular processes. | ||||||
Mdivi-1 | 338967-87-6 | sc-215291 sc-215291B sc-215291A sc-215291C | 5 mg 10 mg 25 mg 50 mg | $67.00 $126.00 $251.00 $465.00 | 13 | |
Mdivi-1, a dynamin-related protein 1 (Drp1) inhibitor, indirectly modulates Intersectin-2 by affecting mitochondrial dynamics. Intersectin-2 interacts with proteins involved in mitochondrial processes, and Mdivi-1-induced alterations in mitochondrial dynamics can impact Intersectin-2 functions and downstream cellular processes. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2, a clathrin inhibitor, directly targets Intersectin-2 by disrupting clathrin-mediated endocytosis. Intersectin-2 interacts with clathrin during endocytic processes, and Pitstop 2 inhibits this interaction, leading to modulation of Intersectin-2 activity and downstream cellular processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin indirectly influences Intersectin-2 by targeting phosphoinositide 3-kinase (PI3K) pathways. Intersectin-2 interacts with proteins involved in PI3K signaling, and Wortmannin-induced alterations in PI3K pathways can impact Intersectin-2 functions and downstream cellular processes. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A, an actin polymerization inhibitor, indirectly modulates Intersectin-2 by affecting actin dynamics. Intersectin-2 interacts with actin filaments, and Latrunculin A-induced alterations in actin polymerization can impact Intersectin-2 functions and downstream cellular processes. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A indirectly influences Intersectin-2 by targeting vesicle trafficking and the Golgi apparatus. Brefeldin A disrupts vesicle transport processes, which can impact the cellular pathways involving Intersectin-2. The modulation of vesicle trafficking by Brefeldin A indirectly influences Intersectin-2 functions and downstream cellular processes. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK666, an Arp2/3 complex inhibitor, indirectly modulates Intersectin-2 by affecting actin polymerization. Intersectin-2 interacts with actin filaments, and CK666-induced alterations in Arp2/3 complex activity can impact Intersectin-2 functions and downstream cellular processes. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $84.00 $297.00 | 4 | |
Exo1, an exocytosis inhibitor, directly targets Intersectin-2 by affecting vesicle release processes. Intersectin-2 is involved in exocytosis regulation, and Exo1 inhibits exocytosis, leading to modulation of Intersectin-2 activity and downstream cellular processes. | ||||||