Integrin VIb Inhibitors
Integrin VIb inhibitors are a class of chemical compounds specifically designed to target the integrin αVβ6 receptor, a member of the integrin family of cell surface receptors involved in mediating cell adhesion and communication with the extracellular matrix (ECM). Integrins are heterodimeric proteins composed of α and β subunits, and they play critical roles in various cellular processes such as cell migration, adhesion, and signaling. The integrin αVβ6 receptor, in particular, is known for its ability to bind ligands like fibronectin and transforming growth factor beta (TGF-β), thereby influencing processes like tissue remodeling and cell-ECM interactions. Inhibitors of integrin VIb (αVβ6) are designed to disrupt these interactions, thereby modulating the signaling pathways that this integrin receptor regulates.
The molecular design of integrin VIb inhibitors typically focuses on blocking the receptor's ligand-binding site, preventing the integrin from interacting with ECM components or other signaling molecules. These inhibitors may mimic the natural ligands of the integrin, compete for binding at key interaction sites, or disrupt the conformational changes required for receptor activation. The interactions between integrin VIb inhibitors and the receptor are usually mediated through non-covalent forces such as hydrogen bonds, ionic interactions, or hydrophobic forces, ensuring specificity and stability. By inhibiting αVβ6, researchers can study the integrin's role in various cellular processes, including its contribution to cell migration, ECM remodeling, and integrin-mediated signaling pathways. Integrin VIb inhibitors provide valuable insights into the functional roles of integrins in cellular dynamics and how their inhibition can alter cell behavior in the context of cell-ECM communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB 431542 might downregulate ITGB6 expression by specifically inhibiting the TGF-β type I receptor ALK5, which, when active, typically upregulates ITGB6 as part of the TGF-β signaling pathway that promotes cell adhesion and migration. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
As a selective inhibitor of the TGF-β type I receptor kinase, LY 364947 could decrease ITGB6 expression by blocking the intracellular signaling cascade that normally results in ITGB6 gene transcription. | ||||||
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1775.00 | ||
Halofuginone may reduce the synthesis of ITGB6 by preventing Smad3 phosphorylation, a critical step in the TGF-β signaling pathway that would otherwise initiate ITGB6 gene transcription. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
Palbociclib could indirectly inhibit ITGB6 expression by arresting the cell cycle in the G1 phase, which may lead to a reduction in the overall levels of ITGB6 as the cell cycle is tightly linked to the expression of various integrins. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
By inhibiting JNK, SP600125 could lead to a decreased activation of AP-1 transcription factor, resulting in the reduced transcriptional activity of the ITGB6 gene. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 could inhibit PI3K, leading to a decrease in AKT phosphorylation and subsequent downregulation of ITGB6 transcription, as PI3K/AKT is a pathway known to be involved in the control of various integrin expressions. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin may inhibit mTOR, which is involved in the regulation of protein translation. This inhibition could lead to a decrease in ITGB6 protein levels by reducing the general protein synthesis machinery in the cell. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide could suppress ITGB6 expression by inhibiting the transcriptional activity of NF-κB and other transcription factors that are upstream regulators of ITGB6 gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, could lead to the hypomethylation of the ITGB6 gene promoter, potentially decreasing its expression by allowing for the binding of transcriptional repressors or changing the structure of chromatin to a more closed conformation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may lead to hyperacetylation of histones, resulting in a less compact chromatin state around the ITGB6 gene promoter, potentially reducing ITGB6 transcription by allowing repressive transcriptional machinery better access to the DNA. | ||||||