ING2 Inhibitors

ING2 inhibitors are a class of compounds that target the Inhibitor of Growth Protein 2 (ING2), a member of the ING family of proteins. ING2 is a nuclear protein that plays a significant role in the regulation of chromatin structure and gene expression. It functions as a part of various chromatin-remodeling complexes, influencing the acetylation status of histones, which in turn controls access to DNA for transcription. ING2 specifically binds to phosphoinositides, such as phosphatidylinositol 5-phosphate (PtdIns5P), which helps regulate its ability to modulate gene expression. Through its association with the p53 tumor suppressor pathway and other chromatin-modifying complexes, ING2 is involved in maintaining genomic stability, regulating cell cycle progression, and modulating stress responses.

Inhibitors of ING2 are designed to interfere with its interaction with chromatin or its binding to specific phosphoinositides, thereby modulating its influence on histone acetylation and gene expression. These inhibitors are useful tools for studying how ING2 controls the transcriptional landscape within cells and how its activity impacts chromatin dynamics. By blocking ING2's function, researchers can explore its role in maintaining chromatin structure, regulating gene expression, and influencing cellular responses to environmental stressors. ING2 inhibitors also allow for detailed investigation into how this protein interacts with other components of chromatin remodeling complexes and how these interactions affect processes such as DNA repair, gene silencing, and the overall maintenance of cellular homeostasis.