IMMP1L Inhibitors
IMMP1L inhibitors are chemicals that indirectly influence the activity of IMMP1L by modulating mitochondrial function and dynamics. These inhibitors target various aspects of mitochondrial physiology, such as ATP synthesis, electron transport, and membrane potential, which are crucial for the proper functioning of mitochondria. Compounds like Oligomycin, Rotenone, and Antimycin A inhibit different complexes of the mitochondrial electron transport chain, thereby reducing ATP production and affecting mitochondrial efficiency. This reduction in mitochondrial function can indirectly modulate the activity of IMMP1L, which is integral to mitochondrial processing.
Other compounds like CCCP and 2-Deoxy-D-glucose disrupt mitochondrial membrane potential and glycolysis, respectively, leading to altered energy dynamics within the cell. This energy disruption is likely to indirectly affect IMMP1L's role in mitochondrial processing. Similarly, chemicals such as Sodium azide and Paraquat, which inhibit mitochondrial complex IV and generate ROS, can impact mitochondrial integrity, potentially leading to the modulation of IMMP1L function. Dinitrophenol (DNP), Atovaquone, and MitoQ, each affecting mitochondrial efficiency and oxidative stress, further contribute to the indirect inhibition of IMMP1L activity. Actinonin and Valinomycin, by inhibiting mitochondrial processing peptidases and disrupting membrane potential, respectively, also play a role in modulating IMMP1L activity indirectly. These chemicals collectively demonstrate the intricate relationship between mitochondrial health, energy dynamics, and the potential indirect modulation of IMMP1L activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin inhibits ATP synthase in mitochondria, leading to reduced ATP production and altered mitochondrial membrane potential. This can indirectly affect mitochondrial processing activities, potentially inhibiting IMMP1L function due to altered energy dynamics within mitochondria. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone inhibits mitochondrial electron transport chain complex I. This inhibition leads to reduced mitochondrial function, which can indirectly affect IMMP1L's role in mitochondrial processing due to compromised mitochondrial efficiency. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits complex III of the mitochondrial electron transport chain, disrupting ATP synthesis. This can indirectly modulate IMMP1L activity by affecting mitochondrial energy status and health. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
CCCP dissipates the mitochondrial membrane potential, leading to a decrease in ATP synthesis. This collapse in membrane potential can indirectly inhibit IMMP1L function by disrupting normal mitochondrial processing and dynamics. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose inhibits glycolysis by blocking hexokinase, leading to reduced ATP production. This energy depletion can indirectly affect IMMP1L function due to decreased energy availability for mitochondrial processing. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits mitochondrial complex IV, impacting cellular respiration and ATP synthesis. This inhibition can lead to an indirect modulation of IMMP1L activity, as mitochondrial processing is energy-dependent. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $149.00 | 7 | |
Paraquat generates reactive oxygen species (ROS) within cells, particularly affecting mitochondria. Increased oxidative stress can indirectly inhibit IMMP1L function by impairing mitochondrial integrity and processing. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $58.00 | 2 | |
DNP uncouples oxidative phosphorylation, leading to inefficient ATP production. This disruption in mitochondrial energy production can indirectly affect IMMP1L's role in mitochondrial processing. | ||||||
Atovaquone | 95233-18-4 | sc-217675 | 10 mg | $265.00 | 2 | |
Atovaquone selectively inhibits mitochondrial electron transport in protozoa. Although its effects on human mitochondria are minimal, it can potentially lead to indirect modulation of IMMP1L by altering mitochondrial function. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $284.00 | ||
MitoQ is targeted to mitochondria due to its lipophilic cationic nature. It can modulate mitochondrial oxidative stress and function, potentially indirectly affecting IMMP1L's role in mitochondrial processing. | ||||||