ILT-8 Inhibitors
Chemical inhibitors of ILT-8 include a variety of compounds that interfere with cellular signaling pathways and post-translational modifications essential for the protein's function. N-Acetyl-D-glucosamine, for instance, can inhibit the glycosylation of proteins. Since glycosylation is critical for the proper folding and function of membrane proteins like ILT-8, the presence of this monosaccharide could lead to the production of ILT-8 proteins that are unable to function correctly on the cell surface. Similarly, Chondroitin sulfate can disrupt the synthesis of proteoglycans, which may alter the extracellular matrix and consequently affect ILT-8 signaling. Moreover, Heparin, by binding to proteins, can compete with natural ligands for binding sites on ILT-8, potentially disrupting its interactions and signal transduction, leading to inhibition of ILT-8's activity.
Other inhibitors target kinases that are likely involved in the signaling pathways utilized by ILT-8. PP2, a Src family kinase inhibitor, can suppress the kinase activity that may be requisite for ILT-8 downstream signaling. Suramin, by interfering with growth factor binding, can inhibit signal transduction pathways that ILT-8 may depend on. PD168393 and Genistein both function as tyrosine kinase inhibitors and can block the signaling cascade necessary for ILT-8's activity. LY294002 and Wortmannin, as PI3K inhibitors, can prevent AKT phosphorylation, which if required for ILT-8 signaling, would result in its functional inhibition. U0126, SB203580, and SP600125 are inhibitors of different kinases within the MAPK pathway; by inhibiting MEK1/2, p38 MAPK, and JNK respectively, these compounds can disrupt the MAPK pathway signaling that ILT-8 may depend on for its functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-D-glucosamine | 7512-17-6 | sc-286377 sc-286377B sc-286377A | 50 g 100 g 250 g | $92.00 $159.00 $300.00 | 1 | |
N-Acetyl-D-glucosamine is a monosaccharide that can inhibit glycosylation. ILT-8 is a receptor that is likely glycosylated as part of its maturation and function. By inhibiting glycosylation, N-Acetyl-D-glucosamine can result in improperly folded ILT-8 proteins, thereby impeding their ability to function properly on the cell surface. | ||||||
Chondroitin Sulfate, Bovine | 9007-28-7 | sc-203888 | 5 g | $92.00 | 1 | |
Chondroitin sulfate is involved in the inhibition of proteoglycan synthesis. Since proteoglycans can be part of the extracellular matrix and impact receptor signaling, the presence of chondroitin sulfate can alter the cellular environment in which ILT-8 operates, potentially inhibiting its function. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $117.00 | 1 | |
Heparin binds to various proteins and can compete with natural ligands for binding sites, potentially inhibiting the interaction between ILT-8 and its ligands. This can disrupt signal transduction and inhibit the functional activity of ILT-8. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin is a polysulfonated naphthylurea that can interfere with growth factor binding and subsequent signaling. As such, it can inhibit signal transduction pathways that ILT-8 may use for its activation, resulting in a functional inhibition of ILT-8. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a Src family kinase inhibitor. If ILT-8's function is dependent on Src family kinase activity for initiating downstream signaling, PP2 would inhibit these kinases, thus inhibiting ILT-8's function. | ||||||
PD 168393 | 194423-15-9 | sc-222138 | 1 mg | $162.00 | 4 | |
PD168393 is an irreversible inhibitor of EGFR tyrosine kinase. By inhibiting EGFR tyrosine kinase, PD168393 can inhibit downstream signaling pathways that may be required for the functional activity of ILT-8, thereby inhibiting its function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor and can inhibit various signaling pathways. If ILT-8 relies on tyrosine kinase signaling for its function, genistein can inhibit this process, leading to a reduction in ILT-8 functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor and by inhibiting PI3K, it can suppress AKT phosphorylation and activity. If ILT-8 requires PI3K/AKT pathway activity for its signaling, then LY294002 can functionally inhibit ILT-8. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. Since ILT-8 may depend on MAPK pathway activity for its function, U0126 can inhibit this pathway, thereby functionally inhibiting ILT-8. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. If ILT-8's function is mediated through p38 MAPK signaling, then inhibiting this kinase can lead to functional inhibition of ILT-8. | ||||||