Interleukin-2 receptor alpha (IL-2Rα) is a crucial component of the IL-2 receptor complex that plays a central role in regulating immune responses. IL-2Rα is primarily expressed on the surface of activated T cells, where it binds to IL-2, a cytokine that is pivotal for T cell proliferation and function. Upon IL-2 binding, IL-2Rα triggers a signaling cascade that activates downstream pathways, including the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. This activation promotes T cell growth, survival, and differentiation. IL-2Rα signaling is intricately involved in immune homeostasis, immune responses to infections, and the regulation of autoimmunity.
IL-2Rα inhibitors are compounds that modulate the IL-2Rα-mediated signaling pathway. These inhibitors can have both direct and indirect effects. Direct inhibitors specifically target the IL-2Rα receptor itself or its downstream signaling components. Monoclonal antibodies like daclizumab and basiliximab directly target IL-2Rα, reducing its availability for binding IL-2 and dampening T cell activation. Indirect inhibitors encompass a broader range of compounds that affect IL-2Rα signaling by targeting pathways or molecules linked to its activation. Janus kinase inhibitors, such as tofacitinib and baricitinib, intervene at the JAK-STAT pathway level, hindering downstream signaling events and attenuating immune responses. Calcineurin inhibitors, such as cyclosporine and tacrolimus, inhibit T cell activation, including IL-2Rα-mediated activation, by blocking the action of key enzymes in the immune signaling cascade.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Immunosuppressant that inhibits IL-2Rα by blocking calcineurin, preventing activation of T cells and cytokine production. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
Calcineurin inhibitor that binds to FKBP12 and inhibits IL-2Rα expression by preventing T cell activation and cytokine release. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor that suppresses IL-2Rα expression by inhibiting T cell proliferation and cytokine signaling. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $128.00 $638.00 | 7 | |
mTOR inhibitor that downregulates IL-2Rα expression, inhibiting T cell activation and cytokine production. | ||||||
Prednisone | 53-03-2 | sc-205816 sc-205816A sc-205816B | 1 g 5 g 25 g | $41.00 $133.00 $663.00 | 2 | |
Glucocorticoid that suppresses IL-2Rα expression by inhibiting NF-κB activation and downstream cytokine signaling. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Synthetic glucocorticoid that downregulates IL-2Rα by inhibiting NF-κB signaling and T cell activation. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $36.00 $107.00 | 1 | |
Immunosuppressant that inhibits IL-2Rα expression by blocking purine synthesis, leading to reduced T cell activation. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Folate antagonist that inhibits IL-2Rα expression by disrupting nucleotide synthesis, suppressing T cell proliferation. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
Purine analog that inhibits IL-2Rα expression by disrupting DNA synthesis and reducing T cell activation. | ||||||