IL-2Rα Antibody (C-9): sc-393326
- IL-2Rα Antibody (C-9) is a mouse monoclonal IgG2b κ IL-2Rα antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 23-49 at the N-terminus of IL-2R of mouse origin
- IL-2R alpha Antibody (C-9) is recommended for detection of IL-2Rα of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-IL-2R alpha Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IL-2Rα Antibody (C-9) for WB applications. These reagents are now offered in bundles with IL-2Rα Antibody (C-9) (see ordering information below).
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SEE ALSO...
IL-2Rα Antibody (C-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects IL-2R alpha protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-2Rα (C-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-2 receptor is a crucial multicomponent complex composed of three subunits: alpha, beta, and gamma, which are essential for high-affinity binding of interleukin-2 (IL-2). IL-2R alpha chain primarily facilitates IL-2 binding, while beta and gamma chains are vital for IL-2-induced activation of signaling pathways that promote T cell growth and differentiation. Common gamma chain (γc) is not only a component of IL-2 receptor but also plays a significant role in other cytokine receptors, such as IL-4R and IL-7R, enhancing their ligand binding capabilities. This intricate interplay underscores IL-2 receptor′s importance in immune responses, making anti-IL-2Rα antibody (C-9) an invaluable tool for researchers studying T cell biology and related immunological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-2Rα Antibody (C-9) References:
- Sera of lung cancer patients affect the release of Th1, Th2 and monocyte-derived cytokines, and the expression of IL-2Ralpha by normal, stimulated mononuclear cells. | Chechlińska, M., et al. 2004. Cell Mol Biol Lett. 9: 69-81. PMID: 15048152
- Cloning of the gamma chain of the human IL-2 receptor. | Takeshita, T., et al. 1992. Science. 257: 379-82. PMID: 1631559
- Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. | Goodwin, RG., et al. 1990. Cell. 60: 941-51. PMID: 2317865
- The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. | Mosley, B., et al. 1989. Cell. 59: 335-48. PMID: 2805066
- Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. | Paterson, DJ., et al. 1987. Mol Immunol. 24: 1281-90. PMID: 2828930
- Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor. | He, YW., et al. 1995. J Immunol. 154: 1596-605. PMID: 7530740
- Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. | Kondo, M., et al. 1993. Science. 262: 1874-7. PMID: 8266076
- Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. | Russell, SM., et al. 1993. Science. 262: 1880-3. PMID: 8266078
- Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression. | Cao, X., et al. 1993. Proc Natl Acad Sci U S A. 90: 8464-8. PMID: 8378320
- The IL-2 receptor complex: its structure, function, and target genes. | Minami, Y., et al. 1993. Annu Rev Immunol. 11: 245-68. PMID: 8476561
- The in vitro effect on T cell function of soluble IL-2Ralpha from advanced ovarian cancer ascites. | Elg, SA., et al. 1997. Gynecol Oncol. 66: 133-7. PMID: 9234933
- Low expression of CD40 and B7 on macrophages infiltrating UV-exposed human skin; role in IL-2Ralpha-T cell activation. | Kremer, IB., et al. 1998. Eur J Immunol. 28: 2936-46. PMID: 9754581
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-2Rα Antibody (C-9) | sc-393326 | 200 µg/ml | $316.00 | |||
IL-2Rα Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-530430 | 200 µg Ab; 10 µg BP | $354.00 | |||
IL-2Rα Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-523906 | 200 µg Ab, 40 µg BP | $354.00 | |||
IL-2Rα Antibody (C-9) AC | sc-393326 AC | 500 µg/ml, 25% agarose | $416.00 | |||
IL-2Rα Antibody (C-9) HRP | sc-393326 HRP | 200 µg/ml | $316.00 | |||
IL-2Rα Antibody (C-9) FITC | sc-393326 FITC | 200 µg/ml | $330.00 | |||
IL-2Rα Antibody (C-9) PE | sc-393326 PE | 200 µg/ml | $343.00 | |||
IL-2Rα Antibody (C-9) Alexa Fluor® 488 | sc-393326 AF488 | 200 µg/ml | $357.00 | |||
IL-2Rα Antibody (C-9) Alexa Fluor® 546 | sc-393326 AF546 | 200 µg/ml | $357.00 | |||
IL-2Rα Antibody (C-9) Alexa Fluor® 594 | sc-393326 AF594 | 200 µg/ml | $357.00 | |||
IL-2Rα Antibody (C-9) Alexa Fluor® 647 | sc-393326 AF647 | 200 µg/ml | $357.00 | |||
IL-2Rα Antibody (C-9) Alexa Fluor® 680 | sc-393326 AF680 | 200 µg/ml | $357.00 | |||
IL-2Rα Antibody (C-9) Alexa Fluor® 790 | sc-393326 AF790 | 200 µg/ml | $357.00 | |||
IL-2Rα (C-9) Neutralizing Peptide | sc-393326 P | 100 µg/0.5 ml | $68.00 |