IL-22Rα1 Activators
IL-22Rα1 Activators encompass a spectrum of chemical compounds that indirectly enhance the receptor's functional activity through modulation of various signaling pathways. Forskolin, through its ability to raise intracellular cAMP levels, can activate PKA, which in turn may phosphorylate proteins within the IL-22Rα1 signaling cascade, amplifying the receptor's signaling capacity. Similarly, PMA activates PKC, which is known to phosphorylate and activate signaling molecules that can augment IL-22Rα1-mediated responses. Curcumin and resveratrol both act on the JAK-STAT pathway, a key signaling route for IL-22Rα1, with curcumin directly activating it and resveratrol modulating it via SIRT1 activation. Additionally, Prostaglandin E2 and Sphingosine-1-phosphate influence cAMP and sphingosine kinase.
Furthermore, PMA and Ionomycin work through the activation of PKC and the modulation of calcium-dependent signaling pathways, respectively, interlinking with the IL-22Rα1 pathwayto potentiate downstream immune responses. Sphingosine-1-phosphate participates in the sphingosine kinase pathway, which has the potential for cross-communication with IL-22Rα1 signal transduction, suggesting a synergistic effect on the receptor's activity. Similarly, ISX-9 and Anisomycin, through their respective influences on cAMP/PKA and JNK signaling pathways, may indirectly enhance IL-22Rα1 signaling, particularly in immunomodulation within neural contexts. Vitamin D3's role in immune regulation is also critical, as it might affect the transcriptional level of proteins involved in the IL-22Rα1 signaling pathway, potentially leading to an upregulation of the receptor's components.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, which can activate PKA. Activated PKA can phosphorylate target proteins that are part of the IL-22Rα1 signaling complex, enhancing the receptor's ability to mediate its effects on immune regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates NF-kB activity, which is involved in the transcriptional regulation of IL-22 and its receptor components. Enhanced NF-kB activity may increase the cellular responsiveness to IL-22, thereby indirectly enhancing IL-22Rα1 signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which can deacetylate proteins that interact with the IL-22Rα1 signaling pathway. This can lead to an enhanced response of IL-22Rα1 to its ligand. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate (S1P) influences the sphingosine kinase pathway, which can cross-talk with IL-22Rα1-mediated signaling, potentially amplifying the downstream immune responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can then phosphorylate components of the IL-22Rα1 signaling cascade, enhancing the receptor's signaling capacity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, leading to increased cAMP levels, similar to forskolin. This enhances PKA activity and could potentiate IL-22Rα1 signaling through phosphorylation of associated proteins. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine can inhibit enzymes that metabolize cAMP, potentially increasing cAMP levels and thereby enhancing PKA activity which could amplify IL-22Rα1 signaling through phosphorylation mechanisms. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can modulate various calcium-dependent signaling pathways intersecting with the IL-22Rα1 pathway, thereby enhancing its functional activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates the JNK signaling pathway, which can influence the activity of transcription factors that govern the expression of proteins involved in the IL-22Rα1 signaling cascade, potentially enhancing receptor signaling. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 modulates immune response and its active form can influence the transcription of various cytokines and their receptors, including potentially upregulating components of the IL-22Rα1 signaling pathway. | ||||||