IL-17RD Activators
IL-17RD Activators refer to a specific group of chemicals that enhance the activity of the protein IL-17RD, a member of the interleukin-17 receptor family, which plays a pivotal role in inflammatory responses and immune system signaling. These activators are known to influence the intricate signaling pathways IL-17RD is involved in, such as the MAPK cascade, which is integral to cellular responses to external stimuli. By influencing this pathway, IL-17RD activators can amplify the protein's signaling efficacy without affecting its expression levels. For instance, certain kinase activators specifically target the branches of the MAPK pathway, leading to a cascade of phosphorylation events that bolster the activity of IL-17RD. This results in a more robust signaling through its pathway, which is critical in the innate immune response and inflammation.
At the molecular level, IL-17RD activators may interact with the protein's intracellular domain, facilitating its interaction with other signaling proteins and enhancing its role as a scaffold protein. These activators might also affect the protein's conformational state, promoting an active configuration that favors signaling through its associated pathways. Additionally, some IL-17RD activators can indirectly elevate the activity of IL-17RD by modulating the levels of secondary messengers within the cell, such as cyclic AMP, which is known to influence various signaling cascades. By altering the balance of these messengers, IL-17RD activators indirectly promote the functional activity of IL-17RD, thereby enhancing its role in cellular communication networks that dictate inflammatory responses. Collectively, these specific biochemical mechanisms underscore the complex yet precise nature of IL-17RD activation, illustrating the sophisticated interplay between chemical compounds and protein signaling functions within the cellular milieu.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing the levels of cyclic AMP (cAMP) in cells. This rise in cAMP activates protein kinase A (PKA). PKA then phosphorylates specific transcription factors, which can lead to the upregulation of IL-17RD expression and enhance its activity in the signaling pathways pertinent to its role in inflammation and immune response. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can trigger a cascade of downstream signaling events that enhance the activity of IL-17RD by modulating its phosphorylation state, which is crucial for its role in immune signaling. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P activates sphingosine-1-phosphate receptors, which can lead to the activation of downstream MAPK and PI3K/Akt signaling pathways. These pathways can converge on the regulation and activity enhancement of IL-17RD, which is involved in inflammatory response modulation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 binds to EP receptors, leading to increased intracellular cAMP. This rise in cAMP can enhance the activity of IL-17RD by the PKA-mediated phosphorylation of proteins involved in IL-17RD mediated signaling, thus enhancing its role in the immune response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor leading to increased cytosolic calcium levels. Elevated intracellular calcium can activate calcium-dependent kinases, such as calcineurin, which can enhance the activity of IL-17RD by influencing its state of phosphorylation and its interactions with other proteins involved in immune response signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore, which increases intracellular calcium levels. Calcium signaling is integral to the function of many proteins, and the subsequent activation of calcium-dependent kinases can modulate the activity of IL-17RD, enhancing its role in immune signaling pathways. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation, which can lead to the alteration of the transcriptional programs controlling IL-17RD expression. By inhibiting competitive NF-κB signaling pathways, BAY 11-7082 can indirectly enhance the activity of IL-17RD through the reduction of inhibitory cross-talk, thus allowing for its signaling pathways to be more predominant. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin exerts multiple effects on cell signaling pathways, including the inhibition of NF-κB. By modulating the NF-κB pathway, curcumin can enhance the activity of IL-17RD by decreasing the inhibitory effects this pathway might exert on IL-17RD-related signaling, thus potentiating its role in immune response pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to modulate the SIRT1 and AMPK signaling pathways, which are involved in cellular stress responses. Activation of these pathways can enhance the functional activity of IL-17RD by modulating cellular stress and survival pathways, which may intersect with IL-17RD signaling in the context of inflammation and immunity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which, by suppressing PI3K/Akt signaling, can shift the balance towards other signaling pathways, potentially enhancing the activity of IL-17RD. By reducing PI3K/Akt-mediated survival signals, IL-17RD-dependent pathways may become more active, thus promoting its functional role in immune signaling. | ||||||